Tbio BHLHE40 Class E basic helix-loop-helix protein 40

Protein Summary

Description

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• O14503
• Q96TD3
• bHLHe40

Gene Name

• BHLHE40

Ensembl ID

• ENST00000256495
• ENSP00000256495
• ENSG00000134107

Symbol

• BHLHB2
• DEC1
• SHARP2
• STRA13
• DEC1
• HLHB2
• BHLHB2
• Clast5
• SHARP2
• STRA13
• Stra14
• SHARP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
transcription factor binding site profile	0.99
virus perturbation	0.99
molecular function	0.97
PubMedID	0.97

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Class E Basic Helix-loop-helix Protein 40

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Class E Basic Helix-loop-helix Protein 40

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.76   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.76   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0