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Tbio
BHLHE40
Class E basic helix-loop-helix protein 40

Protein Summary
Description
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. This gene encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256495
  • ENSP00000256495
  • ENSG00000134107

Symbol
  • BHLHB2
  • DEC1
  • SHARP2
  • STRA13
  • DEC1
  • HLHB2
  • BHLHB2
  • Clast5
  • SHARP2
  • STRA13
  • Stra14
  • SHARP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor binding site profile
0.99
virus perturbation
0.99
molecular function
0.97
PubMedID
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.18   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.18   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
20.1
balding measurement
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
20.1
balding measurement
1
6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member e40
VGNC:5026
460136
Mouse
MGI:1097714
20893
Rat
RGD:68439
79431
Dog
basic helix-loop-helix family member e40
VGNC:38446
484680
Horse
basic helix-loop-helix family member e40
VGNC:15822
100059809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member e40
Mouse
Rat
Dog
basic helix-loop-helix family member e40
Horse
basic helix-loop-helix family member e40
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14503-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Gene Ontology Terms (30)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (97)
1 – 10 of 97
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999709717
p_ni: 1.4e-8
p_wrong: 0.000290269
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.864317538
p_ni: 1e-8
p_wrong: 0.135682452
Score: 0.464
Data Source: BioPlex,STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
Score: 0.983
Data Source: STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.00728451
Score: 0.98
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
Score: 0.959
Data Source: STRINGDB
DEC1
Tbio
Novelty: 0.09627576
Score: 0.949
Data Source: STRINGDB
BHLHE41
Tbio
Family: TF
Novelty: 0.01015053
Score: 0.922
Data Source: STRINGDB
HES1
Tbio
Family: TF
Novelty: 0.00974115
Score: 0.904
Data Source: STRINGDB
RMI1
Tbio
Novelty: 0.01222442
Score: 0.9
Data Source: STRINGDB
FANCB
Tbio
Novelty: 0.00268111
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.18

PubMed score by year
PubTator Score  49.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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