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Tbio
ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249842
  • ENSP00000249842
  • ENSG00000129009
  • ENST00000395118
  • ENSP00000378550

Symbol
  • Meflin
  • HsT17563
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.83
gene perturbation
0.74
cell line
0.59
tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
1
2
2
83.6
1
1
1
49.5
glomerular filtration rate
1
1
1
49.5
BMI-adjusted hip circumference
1
2
2
47.5
diastolic blood pressure
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
2
83.6
1
49.5
glomerular filtration rate
1
49.5
BMI-adjusted hip circumference
2
47.5
diastolic blood pressure
1
44.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily containing leucine rich repeat
VGNC:6462
748982
Macaque
immunoglobulin superfamily containing leucine rich repeat
701479
Mouse
MGI:1349645
26968
Rat
RGD:1596359
686539
Dog
immunoglobulin superfamily containing leucine rich repeat
VGNC:42110
487643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily containing leucine rich repeat
Macaque
immunoglobulin superfamily containing leucine rich repeat
Mouse
Rat
Dog
immunoglobulin superfamily containing leucine rich repeat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14498-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (132)
1 – 10 of 132
ZRANB3
Tbio
Family:  Enzyme
Novelty:  0.00398767
p_int:  0.999993691
p_ni:  0.000006287
p_wrong:  2.2e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
CDC6
Tbio
Novelty:  0.00219371
p_int:  0.999465872
p_ni:  0.000534128
Data Source:  BioPlex
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.998909954
p_ni:  0.001090046
Score:  0.448
Data Source:  BioPlex,STRINGDB
ACOT9
Tbio
Family:  Enzyme
Novelty:  0.17405187
p_int:  0.997985537
p_ni:  0.002014463
Data Source:  BioPlex
RTEL1
Tbio
Family:  Enzyme
Novelty:  0.00761538
p_int:  0.996904167
p_ni:  0.003095833
Data Source:  BioPlex
ZNF562
Tdark
Family:  TF
Novelty:  12.38372093
p_int:  0.995857255
p_ni:  0.004142745
Data Source:  BioPlex
CNPY4
Tdark
Novelty:  0.59578334
p_int:  0.994824097
p_ni:  0.001066071
p_wrong:  0.004109832
Score:  0.527
Data Source:  BioPlex,STRINGDB
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
p_int:  0.992744501
p_ni:  0.00725368
p_wrong:  0.00000182
Score:  0.207
Data Source:  BioPlex,STRINGDB
USP3
Tbio
Family:  Enzyme
Novelty:  0.02331328
p_int:  0.991560175
p_ni:  0.001252915
p_wrong:  0.00718691
Score:  0.207
Data Source:  BioPlex,STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.98866581
p_ni:  0.011334092
p_wrong:  9.8e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  43.50

PubMed score by year
PubTator Score  1.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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