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Tbio
ARID1A
AT-rich interactive domain-containing protein 1A

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324856
  • ENSP00000320485
  • ENSG00000117713
  • ENST00000374152
  • ENSP00000363267
  • ENST00000457599
  • ENSP00000387636

Symbol
  • BAF250
  • BAF250A
  • C1orf4
  • OSA1
  • SMARCF1
  • ELD
  • B120
  • CSS2
  • OSA1
  • P270
  • hELD
  • BM029
  • MRD14
  • hOSA1
  • BAF250
  • C1orf4
  • BAF250a
  • SMARCF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.96
interacting protein
0.89
biological process
0.85
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.74   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.74   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (206)
1 – 10 of 206
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.99960275
p_ni:  0.00039725
Score:  0.995
Data Source:  BioPlex,STRINGDB
SS18
Tbio
Novelty:  0.00915548
p_int:  0.998421572
p_ni:  0.001578428
Score:  0.967
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.998383171
p_ni:  0.001616829
Score:  0.991
Data Source:  BioPlex,STRINGDB
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  0.997706466
p_ni:  0.002293534
Score:  0.959
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.997431677
p_ni:  0.002568323
Score:  0.918
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.997228559
p_ni:  0.002771441
Score:  0.997
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.996379221
p_ni:  0.003620779
Score:  0.996
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.993099607
p_ni:  0.006900393
Score:  0.933
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.93889909
p_ni:  0.06110091
Score:  0.997
Data Source:  BioPlex,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.760039758
p_ni:  0.239960242
Data Source:  BioPlex
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
4
10
94.3
triglyceride measurement
6
4
7
93.6
monocyte percentage of leukocytes
2
2
2
90.4
low density lipoprotein cholesterol measurement
5
3
6
89.3
sex hormone-binding globulin measurement
6
1
6
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
94.3
triglyceride measurement
7
93.6
monocyte percentage of leukocytes
2
90.4
low density lipoprotein cholesterol measurement
6
89.3
sex hormone-binding globulin measurement
6
88.2
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 1A
VGNC:6722
456665
Macaque
AT-rich interaction domain 1A
719949
Mouse
MGI:1935147
93760
Rat
RGD:1310500
297867
Dog
AT-rich interaction domain 1A
VGNC:38093
487352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 1A
Macaque
AT-rich interaction domain 1A
Mouse
Rat
Dog
AT-rich interaction domain 1A
Publication Statistics
PubMed Score 549.74
PubMed score by year
PubTator Score 265.25
PubTator score by year