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Tbio
PLPP3
Phospholipid phosphatase 3

Protein Summary
Description
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371250
  • ENSP00000360296
  • ENSG00000162407

Symbol
  • LPP3
  • PPAP2B
  • LPP3
  • VCIP
  • Dri42
  • PAP2B
  • PPAP2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
9
6
1.1
95.9
testosterone measurement
2
2
2
83.4
heel bone mineral density
2
1
2
64.2
reticulocyte count
4
1
4
47.6
1
1
0
1.1
41.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.1
95.9
testosterone measurement
2
83.4
heel bone mineral density
2
64.2
reticulocyte count
4
47.6
0
1.1
41.9
Pathways (27)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (137)
1 – 10 of 137
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.998716837
p_ni: 1.93e-7
p_wrong: 0.00128297
Data Source: BioPlex
SGPP2
Tbio
Family: Enzyme
Novelty: 0.09408823
Score: 0.97
Data Source: STRINGDB
SGPP1
Tbio
Family: Enzyme
Novelty: 0.0514048
Score: 0.968
Data Source: STRINGDB
SPHK2
Tchem
Family: Kinase
Novelty: 0.00454527
Score: 0.965
Data Source: STRINGDB
SGPL1
Tchem
Family: Enzyme
Novelty: 0.00272574
Score: 0.963
Data Source: STRINGDB
SPHK1
Tchem
Family: Kinase
Novelty: 0.00147889
Score: 0.956
Data Source: STRINGDB
AGPAT4
Tbio
Family: Enzyme
Novelty: 0.10376004
Score: 0.932
Data Source: STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
Score: 0.931
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.01820899
Score: 0.928
Data Source: STRINGDB
CEPT1
Tbio
Family: Enzyme
Novelty: 0.01816476
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  72.39

PubMed score by year
PubTator Score  39.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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