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Tbio
PLPP1
Phospholipid phosphatase 1

Protein Summary
Description
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264775
  • ENSP00000264775
  • ENSG00000067113
  • ENST00000307259
  • ENSP00000302229

Symbol
  • LPP1
  • PPAP2A
  • LPP1
  • PAP2
  • LLP1a
  • PAP-2a
  • PPAP2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
7
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
95.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase 1
VGNC:4130
461869
Macaque
phospholipid phosphatase 1
706539
Mouse
MGI:108412
19012
Rat
RGD:621832
64369
Dog
phospholipid phosphatase 1
VGNC:44705
607962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase 1
Macaque
phospholipid phosphatase 1
Mouse
Rat
Dog
phospholipid phosphatase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14494-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Protein-Protein Interactions (50)
1 – 10 of 50
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.82203043
p_ni: 0.177969551
p_wrong: 1.9e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.959
Data Source: STRINGDB
AGPAT3
Tbio
Family: Enzyme
Novelty: 0.06139822
Score: 0.949
Data Source: STRINGDB
AGPAT1
Tbio
Family: Enzyme
Novelty: 0.05245441
Score: 0.944
Data Source: STRINGDB
AGPAT2
Tchem
Family: Enzyme
Novelty: 0.01321334
Score: 0.939
Data Source: STRINGDB
AGPAT4
Tbio
Family: Enzyme
Novelty: 0.10376004
Score: 0.938
Data Source: STRINGDB
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.937
Data Source: STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
Score: 0.932
Data Source: STRINGDB
DGAT2
Tchem
Family: Enzyme
Novelty: 0.00488581
Score: 0.927
Data Source: STRINGDB
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.13

PubMed score by year
PubTator Score  70.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer