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Tbio
CLDN4
Claudin-4

Protein Summary
Description
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340958
  • ENSP00000342445
  • ENSG00000189143
  • ENST00000431918
  • ENSP00000388639
  • ENST00000435050
  • ENSP00000409544

Symbol
  • CPER
  • CPETR1
  • WBSCR8
  • CPER
  • CPE-R
  • CPETR
  • CPETR1
  • WBSCR8
  • hCPE-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
transcription factor binding site profile
0.69
disease perturbation
0.68
disease
0.67
chemical
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.01   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 532   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.01   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1313314
12740
Rat
RGD:1307932
304407
Dog
claudin 4
VGNC:39321
100856416
Horse
claudin 4
VGNC:16596
100059948
Cow
claudin 4
VGNC:27416
414921
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
claudin 4
Horse
claudin 4
Cow
claudin 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14493-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (118)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Protein-Protein Interactions (126)
1 – 10 of 126
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.979
Data Source: STRINGDB
OCLN
Tbio
Novelty: 0.00047671
Score: 0.947
Data Source: STRINGDB
CLDN7
Tbio
Novelty: 0.00722366
Score: 0.937
Data Source: STRINGDB
CLDN3
Tbio
Novelty: 0.00286252
Score: 0.933
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.93
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.919
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.915
Data Source: STRINGDB
CLDN8
Tbio
Novelty: 0.02218455
Score: 0.912
Data Source: STRINGDB
CLDN18
Tbio
Novelty: 0.01299528
Score: 0.911
Data Source: STRINGDB
CLDN1
Tbio
Novelty: 0.00505039
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  448.01

PubMed score by year
PubTator Score  333

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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