Tbio CLDN4 Claudin-4

Protein Summary

Description

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O14493

Gene Name

• CLDN4

Ensembl ID

• ENST00000340958
• ENSP00000342445
• ENSG00000189143
• ENST00000431918
• ENSP00000388639
• ENST00000435050
• ENSP00000409544

Symbol

• CPER
• CPETR1
• WBSCR8
• CPER
• CPE-R
• CPETR
• CPETR1
• WBSCR8
• hCPE-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
transcription factor binding site profile	0.69
disease perturbation	0.68
disease	0.67
chemical	0.62

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-4

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.73   (req: < 5)

Gene RIFs: 144   (req: <= 3)

Antibodies: 532   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.73   (req: >= 5)

Gene RIFs: 144   (req: > 3)

Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0