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Tbio
SH2B2
SH2B adapter protein 2

Protein Summary
Description
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536178
  • ENSP00000440273
  • ENSG00000160999

Symbol
  • APS
  • APS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.75
tissue
0.62
cell line
0.6
cellular component
0.6
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
71.3
eosinophil count
1
1
1
67.3
C-reactive protein measurement
1
1
1
56.8
insomnia measurement
1
2
0
1
54.2
glomerular filtration rate
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
71.3
eosinophil count
1
67.3
C-reactive protein measurement
1
56.8
insomnia measurement
0
1
54.2
glomerular filtration rate
1
40.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 2
VGNC:4506
741557
Macaque
SH2B adaptor protein 2
714861
Mouse
MGI:1345171
23921
Rat
RGD:69284
114203
Dog
SH2B adaptor protein 2
489820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 2
Macaque
SH2B adaptor protein 2
Mouse
Rat
Dog
SH2B adaptor protein 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14492-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (111)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Regulation of KIT signaling
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Regulation of KIT signaling
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (71)
1 – 10 of 71
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999999778
p_ni:  5e-9
p_wrong:  2.17e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.992
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.966
Data Source:  Reactome,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.963
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.959
Data Source:  Reactome,STRINGDB
SORBS1
Tbio
Novelty:  0.01480301
Score:  0.955
Data Source:  STRINGDB
KIT
Tclin
Family:  Kinase
Novelty:  0.00011237
Score:  0.949
Data Source:  Reactome,STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.935
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.934
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.45

PubMed score by year
PubTator Score  30.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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