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Tbio
DLGAP1
Disks large-associated protein 1

Protein Summary
Description
Part of the postsynaptic scaffold in neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315677
  • ENSP00000316377
  • ENSG00000170579
  • ENST00000400145
  • ENSP00000383010
  • ENST00000400147
  • ENSP00000383011
  • ENST00000400155
  • ENSP00000383019
  • ENST00000534970
  • ENSP00000437817
  • ENST00000539435
  • ENSP00000446312
  • ENST00000581527
  • ENSP00000463864
  • ENST00000581699
  • ENSP00000462848

Symbol
  • DAP1
  • GKAP
  • DAP1
  • GKAP
  • DAP-1
  • SAPAP1
  • DLGAP1A
  • DLGAP1B
  • DAP-1-BETA
  • DAP-1-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
hub protein
0.98
microRNA
0.89
transcription factor
0.75
phenotype
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.15   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.15   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
92.4
age at menarche
2
2
2
61.6
smoking status measurement
1
1
1
44.5
eyelid sagging measurement
1
1
1
35.9
puberty onset measurement
1
1
1
35.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
92.4
age at menarche
2
61.6
smoking status measurement
1
44.5
eyelid sagging measurement
1
35.9
puberty onset measurement
1
35.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 1
VGNC:13255
455311
Mouse
MGI:1346065
224997
Rat
RGD:620223
65040
Dog
DLG associated protein 1
VGNC:39979
480194
Horse
DLG associated protein 1
VGNC:17212
100051510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 1
Mouse
Rat
Dog
DLG associated protein 1
Horse
DLG associated protein 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (140)
1 – 10 of 140
DLG4
Tchem
Novelty: 0.00057285
Score: 0.999
Data Source: Reactome,STRINGDB
SHANK1
Tbio
Novelty: 0.01475447
Score: 0.996
Data Source: Reactome,STRINGDB
SHANK2
Tbio
Novelty: 0.00710548
Score: 0.994
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.993
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.99
Data Source: Reactome,STRINGDB
DLGAP3
Tbio
Novelty: 0.02019435
Score: 0.989
Data Source: STRINGDB
DLGAP2
Tbio
Novelty: 0.02137009
Score: 0.989
Data Source: STRINGDB
HOMER1
Tbio
Novelty: 0.00264721
Score: 0.978
Data Source: Reactome,STRINGDB
GRM1
Tchem
Family: GPCR
Novelty: 0.00099764
Score: 0.975
Data Source: Reactome,STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.972
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  60.15

PubMed score by year
PubTator Score  25.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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