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Tchem
SCD
Acyl-CoA desaturase

Protein Summary
Description
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturas ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
gene perturbation
0.98
small molecule perturbation
0.93
transcription factor perturbation
0.91
kinase perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1785.27   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1785.27   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 537
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (195)
PANK2
Tbio
Family:  Kinase
Novelty:  0.00465551
p_int:  0.999953738
p_ni:  0.000046262
Data Source:  BioPlex
PANK1
Tbio
Family:  Kinase
Novelty:  0.00870107
p_int:  0.999900689
p_ni:  0.000099304
p_wrong:  7e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
SREBF1
Tchem
Family:  TF
Novelty:  0.00055257
Score:  0.937
Data Source:  STRINGDB
ACOT1
Tbio
Family:  Enzyme
Novelty:  0.01211801
Score:  0.927
Data Source:  STRINGDB
ACOT4
Tbio
Family:  Enzyme
Novelty:  0.13441184
Score:  0.918
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.912
Data Source:  STRINGDB
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
Score:  0.911
Data Source:  STRINGDB
CYB5A
Tbio
Novelty:  0.00047376
Score:  0.905
Data Source:  STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.896
Data Source:  STRINGDB
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
Score:  0.89
Data Source:  STRINGDB
Pathways (21)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
1
6
94.2
metabolite measurement
1
1
1
93.6
lysophosphatidylcholine measurement
3
3
4
12.5
92.2
heel bone mineral density
3
1
4
89.3
fatty acid measurement
5
1
5
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
94.2
metabolite measurement
1
93.6
lysophosphatidylcholine measurement
4
12.5
92.2
heel bone mineral density
4
89.3
fatty acid measurement
5
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stearoyl-CoA desaturase
VGNC:10458
450676
Macaque
stearoyl-CoA desaturase
710155
Mouse
MGI:98240
20250
Rat
RGD:621177
83792
Dog
stearoyl-CoA desaturase
VGNC:45900
486839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stearoyl-CoA desaturase
Macaque
stearoyl-CoA desaturase
Mouse
Rat
Dog
stearoyl-CoA desaturase
Publication Statistics
PubMed Score 1785.27
PubMed score by year
PubTator Score 456.18
PubTator score by year
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Related Publications
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PMID
Year
Title