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Tbio
PDXK
Pyridoxal kinase

Protein Summary
Description
Required for synthesis of pyridoxal-5-phosphate from vitamin B6. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291565
  • ENSP00000291565
  • ENSG00000160209
  • ENST00000468090
  • ENSP00000418359

Symbol
  • C21orf124
  • C21orf97
  • PKH
  • PNK
  • PKH
  • PNK
  • PRED79
  • C21orf97
  • HEL-S-1a
  • C21orf124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.99
interacting protein
0.93
drug perturbation
0.87
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0