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Tbio
PDXK
Pyridoxal kinase

Protein Summary
Description
Required for synthesis of pyridoxal-5-phosphate from vitamin B6. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291565
  • ENSP00000291565
  • ENSG00000160209
  • ENST00000468090
  • ENSP00000418359

Symbol
  • C21orf124
  • C21orf97
  • PKH
  • PNK
  • PKH
  • PNK
  • PRED79
  • C21orf97
  • HEL-S-1a
  • C21orf124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.99
interacting protein
0.93
drug perturbation
0.87
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
72.3
eosinophil count
2
2
2
59.4
cystatin B measurement
1
1
1
52
blood protein measurement
1
1
1
47.5
mean corpuscular volume
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
72.3
eosinophil count
2
59.4
cystatin B measurement
1
52
blood protein measurement
1
47.5
mean corpuscular volume
1
44.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridoxal kinase
VGNC:14678
737076
Macaque
pyridoxal kinase
713564
Mouse
MGI:1351869
216134
Rat
RGD:621324
83578
Dog
pyridoxal kinase
VGNC:49939
487788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridoxal kinase
Macaque
pyridoxal kinase
Mouse
Rat
Dog
pyridoxal kinase
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00764-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (143)
1 – 10 of 143
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
Score:  0.99
Data Source:  STRINGDB
PDXP
Tbio
Family:  Enzyme
Novelty:  0.01015805
Score:  0.939
Data Source:  STRINGDB
NIT2
Tbio
Family:  Enzyme
Novelty:  0.01003111
Score:  0.914
Data Source:  STRINGDB
ORM1
Tbio
Novelty:  0.007451
Score:  0.909
Data Source:  STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
Score:  0.908
Data Source:  STRINGDB
ORM2
Tbio
Novelty:  0.00837073
Score:  0.908
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.907
Data Source:  STRINGDB
SPTAN1
Tbio
Novelty:  0.00286901
Score:  0.906
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.905
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.905
Data Source:  STRINGDB
Publication Statistics
PubMed Score  111.31

PubMed score by year
PubTator Score  79.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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