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Tchem
ACACB
Acetyl-CoA carboxylase 2

Protein Summary
Description
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338432
  • ENSP00000341044
  • ENSG00000076555
  • ENST00000377848
  • ENSP00000367079

Symbol
  • ACC2
  • ACCB
  • ACC2
  • ACCB
  • HACC275
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.98
interacting protein
0.74
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.67   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.67   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2501
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
38.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
38.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA carboxylase beta
VGNC:4913
452219
Mouse
MGI:2140940
100705
Rat
RGD:620500
116719
Dog
acetyl-CoA carboxylase beta
VGNC:37490
100685468
Horse
acetyl-CoA carboxylase beta
VGNC:14962
100066740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA carboxylase beta
Mouse
Rat
Dog
acetyl-CoA carboxylase beta
Horse
acetyl-CoA carboxylase beta
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Biotin transport and metabolism
Reactome
ChREBP activates metabolic gene expression
Reactome
Integration of energy metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Biotin transport and metabolism
ChREBP activates metabolic gene expression
Integration of energy metabolism
Metabolism
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (116)
1 – 10 of 116
THRSP
Tbio
Novelty: 0.00938864
p_int: 0.999999794
p_ni: 2.06e-7
Score: 0.434
Data Source: BioPlex,STRINGDB
RGS1
Tbio
Novelty: 0.01038943
p_int: 0.988122026
p_ni: 0.011796117
p_wrong: 0.000081857
Score: 0.692
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.914049794
p_ni: 0.00173881
p_wrong: 0.084211396
Data Source: BioPlex
FASN
Tchem
Family: Enzyme
Novelty: 0.00142172
Score: 0.988
Data Source: STRINGDB
HLCS
Tchem
Family: Enzyme
Novelty: 0.01597449
Score: 0.985
Data Source: Reactome,STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00114812
Score: 0.981
Data Source: STRINGDB
MCAT
Tbio
Family: Enzyme
Novelty: 0.00600508
Score: 0.975
Data Source: STRINGDB
ACSS2
Tbio
Family: Enzyme
Novelty: 0.00448879
Score: 0.959
Data Source: STRINGDB
CPT1A
Tchem
Family: Enzyme
Novelty: 0.00281783
Score: 0.943
Data Source: STRINGDB
PRKAA2
Tchem
Family: Kinase
Novelty: 0.01795523
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  206.67

PubMed score by year
PubTator Score  118.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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