Tchem ACACB Acetyl-CoA carboxylase 2

Protein Summary

Description

Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00763
• A6NK36
• Q16852
• Q1HEC1
• Q6KE87
• Q6KE89
• Q6TY48

Gene Name

• ACACB

Ensembl ID

• ENST00000338432
• ENSP00000341044
• ENSG00000076555
• ENST00000377848
• ENSP00000367079

Symbol

• ACC2
• ACCB
• ACC2
• ACCB
• HACC275

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
biological process	0.98
interacting protein	0.74
transcription factor perturbation	0.74

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.67   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.67   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2501

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2501)

Explore Active Ligands

1 – 10 of 2501

CHEMBL3967050

ACACBTchem Enzyme

IC50 : 6.01

CHEMBL568155

ACACBTchem Enzyme

IC50 : 6.03

CHEMBL3904572

ACACBTchem Enzyme

IC50 : 6.03

CHEMBL3968401

ACACBTchem Enzyme

IC50 : 6.43

CHEMBL3699844

ACACBTchem Enzyme

IC50 : 6.14

CHEMBL566860

ACACBTchem Enzyme

IC50 : 6.14

CHEMBL3906239

ACACBTchem Enzyme

IC50 : 6.16

CHEMBL568145

ACACBTchem Enzyme

IC50 : 6.21

CHEMBL3934157

ACACBTchem Enzyme

IC50 : 6.24

CHEMBL3896396

ACACBTchem Enzyme

IC50 : 6.23

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2	2	2		38.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2		38.4

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	acetyl-CoA carboxylase beta	VGNC:4913	452219
Mouse	acetyl-Coenzyme A carboxylase beta	MGI:2140940	100705
Rat	acetyl-CoA carboxylase beta	RGD:620500	116719
Dog	acetyl-CoA carboxylase beta	VGNC:37490	100685468
Horse	acetyl-CoA carboxylase beta	VGNC:14962	100066740

Species	Name	OMA	EggNOG	Inparanoid
Chimp	acetyl-CoA carboxylase beta
Mouse	acetyl-Coenzyme A carboxylase beta
Rat	acetyl-CoA carboxylase beta
Dog	acetyl-CoA carboxylase beta
Horse	acetyl-CoA carboxylase beta

Protein Structure (11 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (29)

Reactome (10)

KEGG (9)

PathwayCommons (2)

UniProt (1)

WikiPathways (7)

Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Reactome	Biotin transport and metabolism	11 targets	R-HSA-196780
Reactome	ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Reactome	Integration of energy metabolism	111 targets	R-HSA-163685
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Biotin transport and metabolism	11 targets	R-HSA-196780
ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Integration of energy metabolism	111 targets	R-HSA-163685
Metabolism	2112 targets	R-HSA-1430728

Gene Ontology Terms (28)

Functions (6)

Components (5)

Processes (17)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
acetyl-CoA carboxylase activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
biotin binding	Inferred from Electronic Annotation (IEA)	Ensembl
biotin carboxylase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (116)

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1 – 10 of 116

• See Interactions on String-DB

THRSP

Tbio

Novelty: 0.00938864

p_int: 0.999999794

p_ni: 2.06e-7

Score: 0.434

Data Source: BioPlex,STRINGDB

RGS1

Tbio

Novelty: 0.01038943

p_int: 0.988122026

p_ni: 0.011796117

p_wrong: 0.000081857

Score: 0.692

Data Source: BioPlex,STRINGDB

HIST1H4A

Tbio

Novelty: 0.00279614

p_int: 0.914049794

p_ni: 0.00173881

p_wrong: 0.084211396

Data Source: BioPlex

FASN

Tchem

Family: Enzyme

Novelty: 0.00142172

Score: 0.988

Data Source: STRINGDB

HLCS

Tchem

Family: Enzyme

Novelty: 0.01597449

Score: 0.985

Data Source: Reactome,STRINGDB

ACLY

Tclin

Family: Enzyme

Novelty: 0.00114812

Score: 0.981

Data Source: STRINGDB

MCAT

Tbio

Family: Enzyme

Novelty: 0.00600508

Score: 0.975

Data Source: STRINGDB

ACSS2

Tbio

Family: Enzyme

Novelty: 0.00448879

Score: 0.959

Data Source: STRINGDB

CPT1A

Tchem

Family: Enzyme

Novelty: 0.00281783

Score: 0.943

Data Source: STRINGDB

PRKAA2

Tchem

Family: Kinase

Novelty: 0.01795523

Score: 0.942

Data Source: STRINGDB

Publication Statistics

PubMed Score  206.67

PubMed score by year

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PubTator Score  118.05

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Allosteric enzyme
Alternative splicing
ATP-binding
Biotin
Complete proteome
Fatty acid biosynthesis
Fatty acid metabolism
Ligase
Lipid biosynthesis

GWAS Trait Find Similar Targets

triglyceride measurement

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
muscle phenotype