Protein Summary
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is ...more
- ENST00000338432
- ENSP00000341044
- ENSG00000076555
- ENST00000377848
- ENSP00000367079
- ACC2
- ACCB
- ACC2
- ACCB
- HACC275
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.98 | ||
interacting protein | 0.74 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.47 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 174 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.47 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 174 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2536
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2536)
Protein-Protein Interactions (116)
THRSP
Novelty: 0.00938864
p_int: 0.999999794
p_ni: 2.06e-7
Score: 0.434
Data Source: BioPlex,STRINGDB
RGS1
Novelty: 0.01038943
p_int: 0.988122026
p_ni: 0.011796117
p_wrong: 0.000081857
Score: 0.692
Data Source: BioPlex,STRINGDB
HIST1H4A
Novelty: 0.00279614
p_int: 0.914049794
p_ni: 0.00173881
p_wrong: 0.084211396
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (29)
Reactome (10)
KEGG (9)
PathwayCommons (2)
UniProt (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Biotin transport and metabolism | ||||
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Integration of energy metabolism | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Biotin transport and metabolism | ||||
ChREBP activates metabolic gene expression | ||||
Integration of energy metabolism | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (5)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 2 | 2 | 95.3 | |||||
platelet count | 2 | 2 | 2 | 94.8 | |||||
triglyceride measurement | 3 | 2 | 3 | 87.5 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 78.5 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 2 | 95.3 | |||||
platelet count | 2 | 94.8 | |||||
triglyceride measurement | 3 | 87.5 | |||||
alkaline phosphatase measurement | 1 | 78.5 | |||||
high density lipoprotein cholesterol measurement | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | acetyl-CoA carboxylase beta | VGNC:4913 | 452219 | |||||
Mouse | MGI:2140940 | 100705 | ||||||
Rat | RGD:620500 | 116719 | ||||||
Dog | acetyl-CoA carboxylase beta | VGNC:37490 | 100685468 | |||||
Horse | acetyl-CoA carboxylase beta | VGNC:14962 | 100066740 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | acetyl-CoA carboxylase beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | acetyl-CoA carboxylase beta | |||||
Horse | acetyl-CoA carboxylase beta | |||||
Publication Statistics
PubMed Score 211.47
PubMed score by year
PubTator Score 118.05
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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