Tbio UBE2C Ubiquitin-conjugating enzyme E2 C

Protein Summary

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• O00762
• A6NP33
• E1P5N7
• G3XAB7

Gene Name

• UBE2C

Ensembl ID

• ENST00000335046
• ENSP00000335674
• ENSG00000175063
• ENST00000352551
• ENSP00000333975
• ENST00000356455
• ENSP00000348838
• ENST00000372568
• ENSP00000361649

Symbol

• UBCH10
• UBCH10
• dJ447F3.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
molecular function	0.96
gene perturbation	0.93
histone modification site profile	0.85
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.39   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 438   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.39   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0