Tbio FBP2 Fructose-1,6-bisphosphatase isozyme 2

Protein Summary

Description

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00757
• Q17R39
• Q6FI53
• FBPase 2

Gene Name

• FBP2

Ensembl ID

• ENST00000375337
• ENSP00000364486
• ENSG00000130957

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
gene perturbation	0.76
cellular component	0.63
molecular function	0.49
pathway	0.47

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Carbohydrate Phosphatase / Fructose-1,6-bisphosphatase Isozyme 2

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Carbohydrate Phosphatase / Fructose-1,6-bisphosphatase Isozyme 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.99   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.99   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0