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Tbio
WNT7A
Protein Wnt-7a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285018
  • ENSP00000285018
  • ENSG00000154764
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
0.72
phenotype
0.69
PubMedID
0.69
gene perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (59)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (71)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (164)
1 – 10 of 164
WNT7B
Tbio
Novelty: 0.01214668
p_int: 0.99999993
p_ni: 7e-9
p_wrong: 6.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT5A
Tbio
Novelty: 0.00148207
p_int: 0.999997711
p_ni: 0.000002288
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.05351568
p_int: 0.999992548
p_ni: 0.000007452
Data Source: BioPlex
MAPK9
Tchem
Family: Kinase
Novelty: 0.00197999
p_int: 0.99996341
p_ni: 0.00003659
Score: 0.22
Data Source: BioPlex,STRINGDB
WLS
Tbio
Novelty: 0.0028553
p_int: 0.999902687
p_ni: 0.000097313
Score: 0.959
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00655436
p_int: 0.995141079
p_ni: 0.004858921
Data Source: BioPlex
NPTX1
Tbio
Novelty: 0.03619614
p_int: 0.994287707
p_ni: 0.005712293
Score: 0.228
Data Source: BioPlex,STRINGDB
FBLN1
Tbio
Novelty: 0.00999502
p_int: 0.993948462
p_ni: 0.006051538
Score: 0.178
Data Source: BioPlex,STRINGDB
CRELD2
Tbio
Novelty: 0.12512198
p_int: 0.992352248
p_ni: 0.007647567
p_wrong: 1.85e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
LOXL2
Tbio
Family: Enzyme
Novelty: 0.00498838
p_int: 0.991755658
p_ni: 0.008244342
Data Source: BioPlex
Publication Statistics
PubMed Score  168.88

PubMed score by year
PubTator Score  94.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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