Tbio WNT7A Protein Wnt-7a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00755
• Q96H90
• Q9Y560

Gene Name

• WNT7A

Ensembl ID

• ENST00000285018
• ENSP00000285018
• ENSG00000154764

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
virus perturbation	0.72
phenotype	0.69
PubMedID	0.69
gene perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-7a

DTO Classes

Protein / Signaling / Protein Wnt-7a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.18   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.18   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (164)

Explore Interacting Targets

1 – 10 of 164

• See Interactions on String-DB

WNT7B

Tbio

Novelty:  0.00684526

p_int:  0.99999993

p_ni:  7e-9

p_wrong:  6.2e-8

Score:  0.923

Data Source:  BioPlex,STRINGDB

WNT5A

Tbio

Novelty:  0.00125563

p_int:  0.999997711

p_ni:  0.000002288

p_wrong:  1e-9

Score:  0.959

Data Source:  BioPlex,STRINGDB

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.999992548

p_ni:  0.000007452

Data Source:  BioPlex

MAPK9

Tchem

Family:  Kinase

Novelty:  0.00267199

p_int:  0.99996341

p_ni:  0.00003659

Score:  0.22

Data Source:  BioPlex,STRINGDB

WLS

Tbio

Novelty:  0.01459149

p_int:  0.999902687

p_ni:  0.000097313

Score:  0.959

Data Source:  BioPlex,STRINGDB

PPP2CA

Tchem

Family:  Enzyme

Novelty:  0.00496839

p_int:  0.995141079

p_ni:  0.004858921

Data Source:  BioPlex

NPTX1

Tbio

Novelty:  0.02872516

p_int:  0.994287707

p_ni:  0.005712293

Score:  0.228

Data Source:  BioPlex,STRINGDB

FBLN1

Tbio

Novelty:  0.00796703

p_int:  0.993948462

p_ni:  0.006051538

Score:  0.178

Data Source:  BioPlex,STRINGDB

CRELD2

Tbio

Novelty:  0.09438775

p_int:  0.992352248

p_ni:  0.007647567

p_wrong:  1.85e-7

Score:  0.167

Data Source:  BioPlex,STRINGDB

LOXL2

Tchem

Family:  Enzyme

Novelty:  0.00599536

p_int:  0.991755658

p_ni:  0.008244342

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (2)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  12

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  8 more common pathways

Pathways (59)

Reactome (6)

KEGG (13)

PathwayCommons (31)

WikiPathways (9)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790
Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790
Signaling by WNT	299 targets	R-HSA-195721

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (71)

Functions (4)

Components (12)

Processes (55)

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1 – 4 of 4

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Direct Assay (IDA)	BHF-UCL
receptor ligand activity	Inferred from Direct Assay (IDA)	BHF-UCL
signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
forced expiratory volume	EFO_0004314	1	1	1		54.4
red blood cell density measurement	EFO_0007978	1	1	1		54.4
vital capacity	EFO_0004312	1	1	1		46.9
glomerular filtration rate	EFO_0005208	2	2	2		46.1
hematocrit	EFO_0004348	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
forced expiratory volume	EFO_0004314	1		54.4
red blood cell density measurement	EFO_0007978	1		54.4
vital capacity	EFO_0004312	1		46.9
glomerular filtration rate	EFO_0005208	2		46.1
hematocrit	EFO_0004348	1		33.1

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UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Developmental protein
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
creatinine measurement
forced expiratory volume
glomerular filtration rate
hematocrit
red blood cell density measurement
schizophrenia
vital capacity

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	Wnt family member 7A		693419
Mouse	wingless-type MMTV integration site family, member 7A	MGI:98961	22421
Rat	Wnt family member 7A	RGD:69079	114850
Dog	Wnt family member 7A	VGNC:48428	607180
Horse	Wnt family member 7A	VGNC:25048	100055450

Species	Name	OMA	EggNOG	Inparanoid
Macaque	Wnt family member 7A
Mouse	wingless-type MMTV integration site family, member 7A
Rat	Wnt family member 7A
Dog	Wnt family member 7A
Horse	Wnt family member 7A

Publication Statistics

PubMed Score 236.18

PubMed score by year

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PubTator Score 94.73

PubTator score by year

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Related Publications

Text Mined References (85)

GeneRif Annotations (57)

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PMID	Year	Title