Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene f ...more
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 236.18 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 185 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 236.18 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 185 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 59
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (164)
WNT7B
Novelty: 0.00684526
p_int: 0.99999993
p_ni: 7e-9
p_wrong: 6.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT5A
Novelty: 0.00125563
p_int: 0.999997711
p_ni: 0.000002288
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
MAPK9
Family: Kinase
Novelty: 0.00267199
p_int: 0.99996341
p_ni: 0.00003659
Score: 0.22
Data Source: BioPlex,STRINGDB
WLS
Novelty: 0.01459149
p_int: 0.999902687
p_ni: 0.000097313
Score: 0.959
Data Source: BioPlex,STRINGDB
PPP2CA
Family: Enzyme
Novelty: 0.00496839
p_int: 0.995141079
p_ni: 0.004858921
Data Source: BioPlex
NPTX1
Novelty: 0.02872516
p_int: 0.994287707
p_ni: 0.005712293
Score: 0.228
Data Source: BioPlex,STRINGDB
FBLN1
Novelty: 0.00796703
p_int: 0.993948462
p_ni: 0.006051538
Score: 0.178
Data Source: BioPlex,STRINGDB
CRELD2
Novelty: 0.09438775
p_int: 0.992352248
p_ni: 0.007647567
p_wrong: 1.85e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
LOXL2
Family: Enzyme
Novelty: 0.00599536
p_int: 0.991755658
p_ni: 0.008244342
Data Source: BioPlex
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (59)
Reactome (6)
KEGG (13)
PathwayCommons (31)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (71)
Functions (4)
Components (12)
Processes (55)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
forced expiratory volume | 1 | 1 | 1 | 54.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 54.4 | |||||
vital capacity | 1 | 1 | 1 | 46.9 | |||||
glomerular filtration rate | 2 | 2 | 2 | 46.1 | |||||
hematocrit | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
forced expiratory volume | 1 | 54.4 | |||||
red blood cell density measurement | 1 | 54.4 | |||||
vital capacity | 1 | 46.9 | |||||
glomerular filtration rate | 2 | 46.1 | |||||
hematocrit | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | Wnt family member 7A | 693419 | ||||||
Mouse | MGI:98961 | 22421 | ||||||
Rat | RGD:69079 | 114850 | ||||||
Dog | Wnt family member 7A | VGNC:48428 | 607180 | |||||
Horse | Wnt family member 7A | VGNC:25048 | 100055450 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | Wnt family member 7A | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 7A | |||||
Horse | Wnt family member 7A | |||||
Publication Statistics
PubMed Score 236.18
PubMed score by year
PubTator Score 94.73
PubTator score by year
Related Publications
Text Mined References (85)
GeneRif Annotations (57)
Items per page:
0 of 0
PMID | Year | Title |
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