Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene f ...more
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.88 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 185 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.88 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 185 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 59
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (59)
Reactome (6)
KEGG (13)
PathwayCommons (31)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Gene Ontology Terms (71)
Functions (4)
Components (12)
Processes (55)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (164)
1 – 10 of 164
WNT7B
Novelty: 0.01214668
p_int: 0.99999993
p_ni: 7e-9
p_wrong: 6.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT5A
Novelty: 0.00148207
p_int: 0.999997711
p_ni: 0.000002288
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
TUBB1
Novelty: 0.05351568
p_int: 0.999992548
p_ni: 0.000007452
Data Source: BioPlex
MAPK9
Family: Kinase
Novelty: 0.00197999
p_int: 0.99996341
p_ni: 0.00003659
Score: 0.22
Data Source: BioPlex,STRINGDB
WLS
Novelty: 0.0028553
p_int: 0.999902687
p_ni: 0.000097313
Score: 0.959
Data Source: BioPlex,STRINGDB
PPP2CA
Family: Enzyme
Novelty: 0.00655436
p_int: 0.995141079
p_ni: 0.004858921
Data Source: BioPlex
NPTX1
Novelty: 0.03619614
p_int: 0.994287707
p_ni: 0.005712293
Score: 0.228
Data Source: BioPlex,STRINGDB
FBLN1
Novelty: 0.00999502
p_int: 0.993948462
p_ni: 0.006051538
Score: 0.178
Data Source: BioPlex,STRINGDB
CRELD2
Novelty: 0.12512198
p_int: 0.992352248
p_ni: 0.007647567
p_wrong: 1.85e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
LOXL2
Family: Enzyme
Novelty: 0.00498838
p_int: 0.991755658
p_ni: 0.008244342
Data Source: BioPlex
Publication Statistics
PubMed Score 168.88
PubMed score by year
PubTator Score 94.73
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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