Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene f ...more

Uniprot Accession IDs

Gene Name

WNT7A

Ensembl ID

ENST00000285018
ENSP00000285018
ENSG00000154764

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

virus perturbation	0.72

phenotype	0.69

PubMedID	0.69

gene perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88 (req: < 5)

View Publications

Gene RIFs: 57 (req: <= 3)

View Gene RIFs

Antibodies: 185 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88 (req: >= 5)

Gene RIFs: 57 (req: > 3)

Antibodies: 185 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (59)

Reactome (6)

KEGG (13)

PathwayCommons (31)

WikiPathways (9)

Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080

Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Reactome	Signal Transduction	2704 targets	R-HSA-162582

Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080

GPCR ligand binding	460 targets	R-HSA-500792

Signal Transduction	2704 targets	R-HSA-162582

Signaling by GPCR	1212 targets	R-HSA-372790

Signaling by WNT	299 targets	R-HSA-195721

Gene Ontology Terms (71)

Functions (4)

Components (12)

Processes (55)

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Direct Assay (IDA)	BHF-UCL

receptor ligand activity	Inferred from Direct Assay (IDA)	BHF-UCL

signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (164)

1 – 10 of 164

See Interactions on String-DB

WNT7B

Tbio

Novelty: 0.01214668

p_int: 0.99999993

p_ni: 7e-9

p_wrong: 6.2e-8

Score: 0.923

Data Source: BioPlex,STRINGDB

WNT5A

Tbio

Novelty: 0.00148207

p_int: 0.999997711

p_ni: 0.000002288

p_wrong: 1e-9

Score: 0.959

Data Source: BioPlex,STRINGDB

TUBB1

Tclin

Novelty: 0.05351568

p_int: 0.999992548

p_ni: 0.000007452

Data Source: BioPlex

MAPK9

Tchem

Family: Kinase

Novelty: 0.00197999

p_int: 0.99996341

p_ni: 0.00003659

Score: 0.22

Data Source: BioPlex,STRINGDB

WLS

Tbio

Novelty: 0.0028553

p_int: 0.999902687

p_ni: 0.000097313

Score: 0.959

Data Source: BioPlex,STRINGDB

PPP2CA

Tchem

Family: Enzyme

Novelty: 0.00655436

p_int: 0.995141079

p_ni: 0.004858921

Data Source: BioPlex

NPTX1

Tbio

Novelty: 0.03619614

p_int: 0.994287707

p_ni: 0.005712293

Score: 0.228

Data Source: BioPlex,STRINGDB

FBLN1

Tbio

Novelty: 0.00999502

p_int: 0.993948462

p_ni: 0.006051538

Score: 0.178

Data Source: BioPlex,STRINGDB

CRELD2

Tbio

Novelty: 0.12512198

p_int: 0.992352248

p_ni: 0.007647567

p_wrong: 1.85e-7

Score: 0.167

Data Source: BioPlex,STRINGDB

LOXL2

Tbio

Family: Enzyme

Novelty: 0.00498838

p_int: 0.991755658

p_ni: 0.008244342

Data Source: BioPlex

Publication Statistics

PubMed Score 168.88

PubMed score by year

PubTator Score 94.73

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword


3D-structure

Complete proteome

Developmental protein

Disease mutation

Disulfide bond

Extracellular matrix

Glycoprotein

Lipoprotein

Reference proteome

Secreted

GWAS Trait

MGI Phenotype


behavior/neurological phenotype

cardiovascular system phenotype

cellular phenotype

embryo phenotype

endocrine/exocrine gland phenotype

integument phenotype

limbs/digits/tail phenotype

mortality/aging

reproductive system phenotype

skeleton phenotype


creatinine measurement

forced expiratory volume

glomerular filtration rate

vital capacity