Protein Summary
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
- ENST00000317091
- ENSP00000317842
- ENSG00000172831
- ENST00000417689
- ENSP00000394452
- ICE
- iCE
- CE-2
- PCE-2
- CES2A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
chemical | 0.81 | ||
tissue sample | 0.76 | ||
PubMedID | 0.73 | ||
cell type or tissue | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 547.79 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 345 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 547.79 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 345 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 100
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (100)
Protein-Protein Interactions (74)
APP
Novelty: 0.00008964
p_int: 0.999999959
p_wrong: 4.1e-8
Score: 0.255
Data Source: BioPlex,STRINGDB
PNMA8A
Novelty: 0.95674878
p_int: 0.998756423
p_ni: 0.001243566
p_wrong: 1.1e-8
Data Source: BioPlex
HIBADH
Family: Enzyme
Novelty: 0.03861647
p_int: 0.994535519
p_ni: 0.005464481
Data Source: BioPlex
PI4K2A
Family: Kinase
Novelty: 0.03506675
p_int: 0.982768449
p_ni: 0.017231551
Data Source: BioPlex
CRELD1
Novelty: 0.04938248
p_int: 0.969615371
p_ni: 0.030384627
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (12)
Reactome (3)
KEGG (1)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 4 | 4 | 87.9 | |||||
high density lipoprotein cholesterol measurement | 2 | 3 | 4 | 83.3 | |||||
heel bone mineral density | 2 | 2 | 2 | 80.6 | |||||
diastolic blood pressure | 1 | 1 | 1 | 73.7 | |||||
blood protein measurement | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 4 | 87.9 | |||||
high density lipoprotein cholesterol measurement | 4 | 83.3 | |||||
heel bone mineral density | 2 | 80.6 | |||||
diastolic blood pressure | 1 | 73.7 | |||||
blood protein measurement | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carboxylesterase 2 | VGNC:5729 | 467996 | |||||
Macaque | cocaine esterase-like | 697524 | ||||||
Mouse | MGI:3648740 | 436059 | ||||||
Rat | RGD:1560889 | 498940 | ||||||
Dog | carboxylesterase 2 | VGNC:39153 | 489769 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carboxylesterase 2 | |||||
Macaque | cocaine esterase-like | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxylesterase 2 | |||||
Publication Statistics
PubMed Score 547.79
PubMed score by year
PubTator Score 449.23
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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