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Tchem
CES2
Cocaine esterase

Protein Summary
Description
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317091
  • ENSP00000317842
  • ENSG00000172831
  • ENST00000417689
  • ENSP00000394452

Symbol
  • ICE
  • iCE
  • CE-2
  • PCE-2
  • CES2A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
chemical
0.81
tissue sample
0.76
PubMedID
0.73
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.79   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.79   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (100)
9,10-phenanthrenequinone
Rendered image for 9,10-phenanthrenequinone
Dihydrotanshinone I
Rendered image for Dihydrotanshinone I
beta-lapachone
Rendered image for beta-lapachone
Tanshinone IIA
Rendered image for Tanshinone IIA
BIA 10-2474
Rendered image for BIA 10-2474
CHEMBL193228
Rendered image for CHEMBL193228
Octadecane-9,10-dione
Rendered image for Octadecane-9,10-dione
Protein-Protein Interactions (74)
APP
Tchem
Novelty:  0.00008964
p_int:  0.999999959
p_wrong:  4.1e-8
Score:  0.255
Data Source:  BioPlex,STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.999992455
p_ni:  0.000007545
Data Source:  BioPlex
PNMA8A
Tdark
Novelty:  0.95674878
p_int:  0.998756423
p_ni:  0.001243566
p_wrong:  1.1e-8
Data Source:  BioPlex
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
p_int:  0.994535519
p_ni:  0.005464481
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.982768449
p_ni:  0.017231551
Data Source:  BioPlex
CRELD1
Tbio
Novelty:  0.04938248
p_int:  0.969615371
p_ni:  0.030384627
p_wrong:  2e-9
Data Source:  BioPlex
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.911935645
p_ni:  0.088064355
Data Source:  BioPlex
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.956
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.93
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.925
Data Source:  STRINGDB
Pathways (12)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
4
4
87.9
high density lipoprotein cholesterol measurement
2
3
4
83.3
heel bone mineral density
2
2
2
80.6
diastolic blood pressure
1
1
1
73.7
blood protein measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
4
87.9
high density lipoprotein cholesterol measurement
4
83.3
heel bone mineral density
2
80.6
diastolic blood pressure
1
73.7
blood protein measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxylesterase 2
VGNC:5729
467996
Macaque
cocaine esterase-like
697524
Mouse
MGI:3648740
436059
Rat
RGD:1560889
498940
Dog
carboxylesterase 2
VGNC:39153
489769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxylesterase 2
Macaque
cocaine esterase-like
Mouse
Rat
Dog
carboxylesterase 2
Publication Statistics
PubMed Score 547.79
PubMed score by year
PubTator Score 449.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title