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Tbio
NME4
Nucleoside diphosphate kinase, mitochondrial

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219479
  • ENSP00000219479
  • ENSG00000103202
  • ENST00000397722
  • ENSP00000380834
  • ENST00000450036
  • ENSP00000389048
  • ENST00000620944
  • ENSP00000479996

Symbol
  • NM23D
  • NDPK-D
  • NM23H4
  • nm23-H4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.8
cellular component
0.76
gene perturbation
0.74
biological process
0.72


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.92   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.92   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NME/NM23 nucleoside diphosphate kinase 4
695649
Mouse
MGI:1931148
56520
Horse
NME/NM23 nucleoside diphosphate kinase 4
VGNC:51174
100066649
Cow
NME/NM23 nucleoside diphosphate kinase 4
789324
Pig
NME/NM23 nucleoside diphosphate kinase 4
100233195
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NME/NM23 nucleoside diphosphate kinase 4
Mouse
Horse
NME/NM23 nucleoside diphosphate kinase 4
Cow
NME/NM23 nucleoside diphosphate kinase 4
Pig
NME/NM23 nucleoside diphosphate kinase 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00746-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (194)
1 – 10 of 194
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
p_int: 0.999977922
p_ni: 0.000022078
Score: 0.847
Data Source: BioPlex,STRINGDB
CD79A
Tbio
Novelty: 0.00118942
p_int: 0.991460706
p_ni: 0.008539291
p_wrong: 3e-9
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.973488651
p_ni: 0.026486373
p_wrong: 0.000024976
Data Source: BioPlex
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.961387885
p_ni: 0.038581887
p_wrong: 0.000030228
Data Source: BioPlex
GLB1L3
Tdark
Family: Enzyme
Novelty: 1.00833616
p_int: 0.95358857
p_ni: 0.046411367
p_wrong: 6.2e-8
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.940700091
p_ni: 0.059299429
p_wrong: 4.79e-7
Data Source: BioPlex
TPP1
Tbio
Family: Enzyme
Novelty: 0.00590008
p_int: 0.919763387
p_ni: 0.080236613
Score: 0.187
Data Source: BioPlex,STRINGDB
CPA5
Tbio
Family: Enzyme
Novelty: 0.0516555
p_int: 0.896195858
p_ni: 0.103804016
p_wrong: 1.26e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
ITGB8
Tbio
Novelty: 0.01564348
p_int: 0.889265867
p_ni: 0.110734133
Score: 0.571
Data Source: BioPlex,STRINGDB
VSIG4
Tbio
Novelty: 0.01671671
p_int: 0.861753384
p_ni: 0.138246454
p_wrong: 1.61e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  27.92

PubMed score by year
PubTator Score  66.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer