Tbio WNT10B Protein Wnt-10b

Protein Summary

Description

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00744
• B2R7A5
• O00747
• Q4VAJ4
• Q4VAJ5
• Q8WZ97

Gene Name

• WNT10B

Ensembl ID

• ENST00000301061
• ENSP00000301061
• ENSG00000169884
• ENST00000407467
• ENSP00000384691

Symbol

• WNT12
• SHFM6
• STHAG8
• WNT-12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
pathway	0.72
PubMedID	0.69
small molecule perturbation	0.64
tissue	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-10b

DTO Classes

Protein / Signaling / Protein Wnt-10b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.18   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.18   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0