Tbio WNT10B Protein Wnt-10b

Protein Summary

Description

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00744
• B2R7A5
• O00747
• Q4VAJ4
• Q4VAJ5
• Q8WZ97

Gene Name

• WNT10B

Ensembl ID

• ENST00000301061
• ENSP00000301061
• ENSG00000169884
• ENST00000407467
• ENSP00000384691

Symbol

• WNT12
• SHFM6
• STHAG8
• WNT-12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
pathway	0.72
PubMedID	0.69
small molecule perturbation	0.64
tissue	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-10b

DTO Classes

Protein / Signaling / Protein Wnt-10b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.71   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.71   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (130)

Explore Interacting Targets

1 – 10 of 130

• See Interactions on String-DB

JMJD8

Tbio

Novelty:  0.31175159

p_int:  0.99918944

p_ni:  0.000810547

p_wrong:  1.3e-8

Score:  0.241

Data Source:  BioPlex,STRINGDB

PPP2R2D

Tbio

Family:  Enzyme

Novelty:  0.0658328

p_int:  0.950401574

p_ni:  0.049598426

Score:  0.163

Data Source:  BioPlex,STRINGDB

FSTL1

Tbio

Novelty:  0.00557848

p_int:  0.924745703

p_ni:  0.075254297

Score:  0.287

Data Source:  BioPlex,STRINGDB

COL6A2

Tbio

Novelty:  0.01275082

p_int:  0.903460457

p_ni:  0.096539543

Score:  0.205

Data Source:  BioPlex,STRINGDB

LRP6

Tbio

Novelty:  0.00305615

p_int:  0.78744615

p_ni:  0.212553849

Score:  0.902

Data Source:  BioPlex,STRINGDB

FZD1

Tchem

Family:  GPCR

Novelty:  0.01097201

Score:  0.974

Data Source:  STRINGDB

FZD2

Tbio

Family:  GPCR

Novelty:  0.00774893

Score:  0.967

Data Source:  STRINGDB

FZD4

Tchem

Family:  GPCR

Novelty:  0.00577957

Score:  0.966

Data Source:  STRINGDB

FZD9

Tbio

Family:  GPCR

Novelty:  0.01414546

Score:  0.964

Data Source:  STRINGDB

FZD6

Tbio

Family:  GPCR

Novelty:  0.01425136

Score:  0.962

Data Source:  STRINGDB

Nearest Tclin Targets (3)

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Upstream (1)

Downstream (2)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  12

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  8 more common pathways

Pathways (61)

Reactome (8)

KEGG (13)

PathwayCommons (29)

WikiPathways (11)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Developmental Biology	1055 targets	R-HSA-1266738
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (39)

Functions (2)

Components (2)

Processes (35)

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GO Term	Evidence	Assigned by
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
receptor ligand activity	Inferred by Curator (IC)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	7	16		99.2
cognitive function measurement	EFO_0008354	3	2	3		86.2
intelligence	EFO_0004337	6	5	4	6.4	82.7
self reported educational attainment	EFO_0004784	4	2	4	6.1	79.3
mathematical ability	EFO_0004875	2	2	2		74.1

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	16		99.2
cognitive function measurement	EFO_0008354	3		86.2
intelligence	EFO_0004337	4	6.4	82.7
self reported educational attainment	EFO_0004784	4	6.1	79.3
mathematical ability	EFO_0004875	2		74.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Developmental protein
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
attention deficit hyperactivity disorder
bipolar disorder
blood protein measurement
body height
body mass index
bone density
cognitive function measurement
HbA1c measurement
heel bone mineral density
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
muscle phenotype
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 10B	VGNC:13496	451870
Mouse	wingless-type MMTV integration site family, member 10B	MGI:108061	22410
Rat	Wnt family member 10B	RGD:1304988	315294
Horse	Wnt family member 10B	VGNC:25042	100051649
Pig	Wnt family member 10B		100126276

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 10B
Mouse	wingless-type MMTV integration site family, member 10B
Rat	Wnt family member 10B
Horse	Wnt family member 10B
Pig	Wnt family member 10B

Publication Statistics

PubMed Score 195.71

PubMed score by year

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PubTator Score 73.36

PubTator score by year

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Related Publications

Text Mined References (50)

GeneRif Annotations (35)

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PMID	Year	Title