Protein Summary
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 1 ...more
- ENST00000301061
- ENSP00000301061
- ENSG00000169884
- ENST00000407467
- ENSP00000384691
- WNT12
- SHFM6
- STHAG8
- WNT-12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
pathway | 0.72 | ||
PubMedID | 0.69 | ||
small molecule perturbation | 0.64 | ||
tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.71 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 209 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.71 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 209 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (130)
JMJD8
Novelty: 0.31175159
p_int: 0.99918944
p_ni: 0.000810547
p_wrong: 1.3e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
PPP2R2D
Family: Enzyme
Novelty: 0.0658328
p_int: 0.950401574
p_ni: 0.049598426
Score: 0.163
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00557848
p_int: 0.924745703
p_ni: 0.075254297
Score: 0.287
Data Source: BioPlex,STRINGDB
COL6A2
Novelty: 0.01275082
p_int: 0.903460457
p_ni: 0.096539543
Score: 0.205
Data Source: BioPlex,STRINGDB
LRP6
Novelty: 0.00305615
p_int: 0.78744615
p_ni: 0.212553849
Score: 0.902
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (61)
Reactome (8)
KEGG (13)
PathwayCommons (29)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Developmental Biology | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
Developmental Biology | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (2)
Components (2)
Processes (35)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred by Curator (IC) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 7 | 16 | 99.2 | |||||
cognitive function measurement | 3 | 2 | 3 | 86.2 | |||||
intelligence | 6 | 5 | 4 | 6.4 | 82.7 | ||||
self reported educational attainment | 4 | 2 | 4 | 6.1 | 79.3 | ||||
mathematical ability | 2 | 2 | 2 | 74.1 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 16 | 99.2 | |||||
cognitive function measurement | 3 | 86.2 | |||||
intelligence | 4 | 6.4 | 82.7 | ||||
self reported educational attainment | 4 | 6.1 | 79.3 | ||||
mathematical ability | 2 | 74.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 10B | VGNC:13496 | 451870 | |||||
Mouse | MGI:108061 | 22410 | ||||||
Rat | RGD:1304988 | 315294 | ||||||
Horse | Wnt family member 10B | VGNC:25042 | 100051649 | |||||
Pig | Wnt family member 10B | 100126276 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | Wnt family member 10B | |||||
Mouse | ||||||
Rat | ||||||
Horse | Wnt family member 10B | |||||
Pig | Wnt family member 10B | |||||
Publication Statistics
PubMed Score 195.71
PubMed score by year
PubTator Score 73.36
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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