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Tbio
PPP6C
Serine/threonine-protein phosphatase 6 catalytic subunit

Protein Summary
Description
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation. This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373547
  • ENSP00000362648
  • ENSG00000119414
  • ENST00000415905
  • ENSP00000411744
  • ENST00000451402
  • ENSP00000392147

Symbol
  • PPP6
  • PP6
  • PP6C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
transcription factor binding site profile
0.92
kinase perturbation
0.88
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.1   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.1   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (173)
1 – 10 of 173
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.996014224
p_ni:  0.003985776
Score:  0.99
Data Source:  BioPlex,STRINGDB
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.935367136
p_ni:  0.064632851
p_wrong:  1.3e-8
Score:  0.919
Data Source:  BioPlex,STRINGDB
PPP6R1
Tbio
Family:  Enzyme
Novelty:  0.0388319
Score:  0.997
Data Source:  Reactome,STRINGDB
PPP6R3
Tbio
Family:  Enzyme
Novelty:  0.00414704
Score:  0.997
Data Source:  Reactome,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
Score:  0.981
Data Source:  Reactome,STRINGDB
IGBP1
Tbio
Novelty:  0.00288273
Score:  0.951
Data Source:  STRINGDB
PTPA
Tchem
Family:  Enzyme
Novelty:  0.00048652
Score:  0.944
Data Source:  STRINGDB
TIPRL
Tbio
Novelty:  0.01885339
Score:  0.934
Data Source:  STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.926
Data Source:  Reactome,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.926
Data Source:  Reactome,STRINGDB
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
1
2
65.9
worry measurement
1
2
0
6.1
50.6
neuroticism measurement
2
2
2
48.5
cigarettes per day measurement
1
1
1
24.5
wellbeing measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
65.9
worry measurement
0
6.1
50.6
neuroticism measurement
2
48.5
cigarettes per day measurement
1
24.5
wellbeing measurement
1
24.5
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 6 catalytic subunit
VGNC:4829
738446
Macaque
protein phosphatase 6 catalytic subunit
703658
Mouse
MGI:1915107
67857
Rat
RGD:708460
171121
Dog
protein phosphatase 6 catalytic subunit
VGNC:49946
608922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 6 catalytic subunit
Macaque
protein phosphatase 6 catalytic subunit
Mouse
Rat
Dog
protein phosphatase 6 catalytic subunit
Publication Statistics
PubMed Score 372.10
PubMed score by year
PubTator Score 32.18
PubTator score by year