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Tbio
E2F3
Transcription factor E2F3

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346618
  • ENSP00000262904
  • ENSG00000112242
  • ENST00000535432
  • ENSP00000443418

Symbol
  • KIAA0075
  • E2F-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor
0.88
microRNA
0.86
disease perturbation
0.83
pathway
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.86   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.86   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (56)
Assembly of the pre-replicative complex (R-HSA-68867)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Gene Ontology Terms (19)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
TFDP2
Tbio
Family: TF
Novelty: 0.27362132
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
TFDP3
Tbio
Family: TF
Novelty: 0.0039422
p_int: 0.999999277
p_ni: 3e-9
p_wrong: 7.2e-7
Score: 0.872
Data Source: BioPlex,STRINGDB
RB1
Tchem
Novelty: 0.00084849
Score: 0.995
Data Source: Reactome,STRINGDB
CCNA2
Tchem
Novelty: 0.00061948
Score: 0.986
Data Source: STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02275414
Score: 0.985
Data Source: Reactome,STRINGDB
RBL1
Tbio
Novelty: 0.00255302
Score: 0.983
Data Source: STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00051528
Score: 0.978
Data Source: STRINGDB
CDK6
Tclin
Family: Kinase
Novelty: 0.00168972
Score: 0.978
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.0001824
Score: 0.976
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.0001824
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  216.86

PubMed score by year
PubTator Score  147.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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