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Tbio
NFIB
Nuclear factor 1 B-type

Protein Summary
Description
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380953
  • ENSP00000370340
  • ENSG00000147862
  • ENST00000380959
  • ENSP00000370346
  • ENST00000543693
  • ENSP00000442888

Symbol
  • CTF
  • MACID
  • NF1-B
  • NFI-B
  • NFIB2
  • NFIB3
  • NF-I/B
  • NFI-RED
  • HMGIC/NFIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
disease perturbation
0.97
virus perturbation
0.88
trait
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.27   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.27   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (71)
1 – 10 of 71
NFIA
Tbio
Family:  TF
Novelty:  0.00754859
p_int:  0.999999292
p_wrong:  7.08e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
NFIX
Tbio
Family:  TF
Novelty:  0.00785778
p_int:  0.999998384
p_wrong:  0.000001616
Score:  0.704
Data Source:  BioPlex,STRINGDB
NFIC
Tbio
Family:  TF
Novelty:  0.00438636
p_int:  0.997310668
p_ni:  5.4e-8
p_wrong:  0.002689278
Score:  0.514
Data Source:  BioPlex,STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.905
Data Source:  STRINGDB
POLR3G
Tbio
Family:  Enzyme
Novelty:  0.04923071
Score:  0.901
Data Source:  STRINGDB
CRCP
Tbio
Family:  Enzyme
Novelty:  0.01111812
Score:  0.9
Data Source:  STRINGDB
POLR2H
Tbio
Family:  Enzyme
Novelty:  0.04008409
Score:  0.9
Data Source:  STRINGDB
POLR1D
Tbio
Novelty:  0.01598347
Score:  0.9
Data Source:  STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.9
Data Source:  STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
Score:  0.9
Data Source:  STRINGDB
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Termination
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
6
92.2
mathematical ability
4
5
6
82.4
3
3
1
1.1
45.2
intelligence
1
1
1
44.2
serum gamma-glutamyl transferase measurement
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
92.2
mathematical ability
6
82.4
1
1.1
45.2
intelligence
1
44.2
serum gamma-glutamyl transferase measurement
2
42.3
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor I B
VGNC:10055
464995
Macaque
nuclear factor I B
714098
Mouse
MGI:103188
18028
Rat
RGD:62015
29227
Dog
nuclear factor I B
VGNC:43776
474709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor I B
Macaque
nuclear factor I B
Mouse
Rat
Dog
nuclear factor I B
Publication Statistics
PubMed Score 196.27
PubMed score by year
PubTator Score 92.74
PubTator score by year