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Tbio
TRIM38
E3 ubiquitin-protein ligase TRIM38

Protein Summary
Description
E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357085
  • ENSP00000349596
  • ENSG00000112343

Symbol
  • RNF15
  • RORET
  • RNF15
  • RORET
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
disease perturbation
0.87
biological process
0.74
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 439   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 439   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (151)
1 – 10 of 151
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.934
Data Source:  STRINGDB
SP100
Tbio
Family:  TF; Epigenetic
Novelty:  0.00201806
Score:  0.932
Data Source:  STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.931
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.93
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.924
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.919
Data Source:  STRINGDB
GBP1
Tbio
Novelty:  0.00634662
Score:  0.916
Data Source:  STRINGDB
GBP2
Tbio
Novelty:  0.01803054
Score:  0.914
Data Source:  STRINGDB
GBP3
Tbio
Novelty:  0.06761345
Score:  0.913
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.913
Data Source:  STRINGDB
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
6
98.2
hemoglobin measurement
2
3
3
96.4
liver iron measurement
1
3
3
95.6
hematocrit
2
3
3
94.3
mean corpuscular hemoglobin concentration
5
2
5
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
98.2
hemoglobin measurement
3
96.4
liver iron measurement
3
95.6
hematocrit
3
94.3
mean corpuscular hemoglobin concentration
5
90.7
Find similar targets by:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 38
694861
Mouse
MGI:2684869
214158
Dog
tripartite motif containing 38
VGNC:47819
488257
Horse
tripartite motif containing 38
VGNC:24507
100052917
Cow
tripartite motif containing 38
VGNC:36333
531022
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 38
Mouse
Dog
tripartite motif containing 38
Horse
tripartite motif containing 38
Cow
tripartite motif containing 38
Publication Statistics
PubMed Score 9.23
PubMed score by year
PubTator Score 7.04
PubTator score by year