Tbio TRIM38 E3 ubiquitin-protein ligase TRIM38

Protein Summary

Description

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• O00635
• B2R862

Gene Name

• TRIM38

Ensembl ID

• ENST00000357085
• ENSP00000349596
• ENSG00000112343

Symbol

• RNF15
• RORET
• RNF15
• RORET

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.99
disease perturbation	0.87
biological process	0.74
gene perturbation	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.42   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 439   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.42   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 439   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0