You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLN
Sarcolipin

Protein Summary
Description
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305991
  • ENSP00000304707
  • ENSG00000170290
  • ENST00000525934
  • ENSP00000434189
  • ENST00000531293
  • ENSP00000435380
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.63
gene perturbation
0.59
cell line
0.58
biological process
0.56
small molecule perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.8   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.8   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (18)
1 – 10 of 18
PLN
Tbio
Novelty:  0.01615063
Score:  0.942
Data Source:  STRINGDB
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
Score:  0.87
Data Source:  STRINGDB
ATP2A2
Tchem
Family:  Transporter
Novelty:  0.00133604
Score:  0.795
Data Source:  STRINGDB
TRAM2
Tbio
Novelty:  0.08830467
Score:  0.757
Data Source:  STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
Score:  0.744
Data Source:  STRINGDB
RYR1
Tclin
Family:  IC
Novelty:  0.00077827
Score:  0.504
Data Source:  STRINGDB
CASQ1
Tbio
Novelty:  0.00815945
Score:  0.489
Data Source:  STRINGDB
CASQ2
Tbio
Novelty:  0.00775794
Score:  0.478
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.476
Data Source:  STRINGDB
TRDN
Tbio
Novelty:  0.00501554
Score:  0.462
Data Source:  STRINGDB
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Find similar targets by:
Publication Statistics
PubMed Score 196.80
PubMed score by year
PubTator Score 834.67
PubTator score by year