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Tbio
KPNA4
Importin subunit alpha-3

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL8 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334256
  • ENSP00000334373
  • ENSG00000186432

Symbol
  • QIP1
  • QIP1
  • SRP3
  • IPOA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.84
interacting protein
0.82
transcription factor binding site profile
0.8
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
51.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
51.6
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (1042)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Host Interactions with Influenza Factors
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Host Interactions with Influenza Factors
ISG15 antiviral mechanism
Protein-Protein Interactions (109)
1 – 10 of 109
IER2
Tbio
Novelty: 0.03864806
p_int: 0.998564488
p_ni: 0.001435512
Score: 0.179
Data Source: BioPlex,STRINGDB
KIF22
Tbio
Novelty: 0.0109594
p_int: 0.998359089
p_ni: 0.001640911
Score: 0.219
Data Source: BioPlex,STRINGDB
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.997418855
p_ni: 0.002581145
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00011248
p_int: 0.981971745
p_ni: 0.018028255
Score: 0.183
Data Source: BioPlex,STRINGDB
MRGBP
Tbio
Novelty: 0.09537142
p_int: 0.981191281
p_ni: 0.018808719
Score: 0.181
Data Source: BioPlex,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
p_int: 0.948549745
p_ni: 0.051450255
Score: 0.807
Data Source: BioPlex,STRINGDB
NUP50
Tbio
Novelty: 0.03424725
p_int: 0.944238941
p_ni: 0.055761059
Score: 0.604
Data Source: BioPlex,STRINGDB
RCC1
Tbio
Novelty: 0.00260884
p_int: 0.943666024
p_ni: 0.056333976
Score: 0.976
Data Source: BioPlex,STRINGDB
NOP56
Tbio
Novelty: 0.01256937
p_int: 0.849358123
p_ni: 0.150641877
Score: 0.238
Data Source: BioPlex,STRINGDB
SOST
Tclin
Novelty: 0.0009273
p_int: 0.847004132
p_ni: 0.152995868
Score: 0.228
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  73.72

PubMed score by year
PubTator Score  21.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer