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Tbio
PEX7
Peroxisomal targeting signal 2 receptor

Protein Summary
Description
Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. This gene encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD). [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318471
  • ENSP00000315680
  • ENSG00000112357
  • ENST00000541292
  • ENSP00000441004

Symbol
  • PTS2R
  • RD
  • PBD9B
  • PTS2R
  • RCDP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein domain
0.73
phenotype
0.71
transcription factor binding site profile
0.7
biological process
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.2   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.2   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
PEX13
Tbio
Novelty:  0.01777214
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
C6orf226
Tdark
Novelty:  4.2303719
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.799
Data Source:  BioPlex,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
p_int:  0.999985173
p_ni:  0.000009345
p_wrong:  0.000005482
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.99997416
p_ni:  0.000025836
p_wrong:  4e-9
Data Source:  BioPlex
IFNA7
Tdark
Novelty:  0.14618009
p_int:  0.999739529
p_ni:  0.000255977
p_wrong:  0.000004495
Data Source:  BioPlex
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.999726883
p_ni:  0.000272982
p_wrong:  1.35e-7
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.997310072
p_ni:  0.002370421
p_wrong:  0.000319508
Score:  0.428
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.996099531
p_ni:  0.003900469
Score:  0.684
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.995903784
p_ni:  0.004096216
Score:  0.263
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.990321779
p_ni:  0.009678221
Score:  0.577
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
3
1.1
95.9
myeloid white cell count
1
1
1
70.5
neutrophil count
2
1
2
70.2
serum non-albumin protein measurement
1
1
1
68.8
blood protein measurement
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
95.9
myeloid white cell count
1
70.5
neutrophil count
2
70.2
serum non-albumin protein measurement
1
68.8
blood protein measurement
1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 7
VGNC:3611
463024
Macaque
peroxisomal biogenesis factor 7
705103
Mouse
MGI:1321392
18634
Rat
RGD:1308483
308718
Dog
peroxisomal biogenesis factor 7
VGNC:44438
484000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 7
Macaque
peroxisomal biogenesis factor 7
Mouse
Rat
Dog
peroxisomal biogenesis factor 7
Publication Statistics
PubMed Score 71.20
PubMed score by year
PubTator Score 54.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title