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Tbio
CCL22
C-C motif chemokine 22

Protein Summary
Description
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219235
  • ENSP00000219235
  • ENSG00000102962

Symbol
  • MDC
  • SCYA22
  • MDC
  • ABCD-1
  • SCYA22
  • STCP-1
  • DC/B-CK
  • A-152E5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
PubMedID
0.77
biological term
0.73
chemical
0.62
disease
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.61   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.61   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (153)
1 – 10 of 153
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.99999937
p_ni:  3.2e-8
p_wrong:  5.97e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
p_int:  0.999997706
p_ni:  0.000002081
p_wrong:  2.13e-7
Data Source:  BioPlex
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.99975395
p_ni:  0.00024605
Data Source:  BioPlex
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.999711658
p_ni:  0.000288342
Score:  0.197
Data Source:  BioPlex,STRINGDB
GLS
Tchem
Family:  Enzyme
Novelty:  0.00321692
p_int:  0.995906026
p_ni:  0.004093974
Data Source:  BioPlex
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.994868374
p_ni:  0.005131626
Data Source:  BioPlex
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
p_int:  0.991217283
p_ni:  0.008782301
p_wrong:  4.16e-7
Data Source:  BioPlex
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.989618389
p_ni:  0.010381501
p_wrong:  1.1e-7
Data Source:  BioPlex
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.98866779
p_ni:  0.009061978
p_wrong:  0.002270232
Data Source:  BioPlex
RAD51D
Tbio
Novelty:  0.01422516
p_int:  0.987301684
p_ni:  0.012698313
p_wrong:  3e-9
Data Source:  BioPlex
Pathways (42)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Dectin-1 mediated noncanonical NF-kB signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Dectin-1 mediated noncanonical NF-kB signaling
Immune System
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
3
3
90.2
CX3CL1 measurement
1
1
1
86.9
CCL17 measurement
1
1
1
79.4
blood protein measurement
1
1
1
76.7
hematocrit
2
2
2
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
90.2
CX3CL1 measurement
1
86.9
CCL17 measurement
1
79.4
blood protein measurement
1
76.7
hematocrit
2
62.6
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1306779
20299
Rat
RGD:619933
117551
Dog
C-C motif chemokine ligand 22
VGNC:38885
100686212
Horse
C-C motif chemokine ligand 22
VGNC:16199
100062332
Cow
C-C motif chemokine ligand 22
VGNC:26949
616996
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
C-C motif chemokine ligand 22
Horse
C-C motif chemokine ligand 22
Cow
C-C motif chemokine ligand 22
Publication Statistics
PubMed Score 363.61
PubMed score by year
PubTator Score 362.67
PubTator score by year