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Tbio
PIR
Pirin

Protein Summary
Description
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380420
  • ENSP00000369785
  • ENSG00000087842
  • ENST00000380421
  • ENSP00000369786
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
virus perturbation
0.85
protein domain
0.73
histone modification site profile
0.68
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.16   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.16   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Protein-Protein Interactions (70)
1 – 10 of 70
C2orf68
Tdark
Novelty: 0.31818182
p_int: 0.999956631
p_ni: 0.000039701
p_wrong: 0.000003668
Score: 0.29
Data Source: BioPlex,STRINGDB
PUF60
Tbio
Novelty: 0.0330882
p_int: 0.999496984
p_ni: 0.00050035
p_wrong: 0.000002666
Data Source: BioPlex
KLHL20
Tbio
Novelty: 0.17747435
p_int: 0.992086641
p_ni: 0.007913319
p_wrong: 4e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00757235
p_int: 0.981686064
p_ni: 0.018312455
p_wrong: 0.00000148
Data Source: BioPlex
WASF2
Tbio
Novelty: 0.00106405
Score: 0.907
Data Source: STRINGDB
PSMA7
Tbio
Family: Enzyme
Novelty: 0.00166058
Score: 0.905
Data Source: STRINGDB
NCKAP1
Tbio
Novelty: 0.06198423
Score: 0.9
Data Source: STRINGDB
ABL2
Tchem
Family: Kinase
Novelty: 0.01240347
Score: 0.9
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00554007
Score: 0.9
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00579565
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  537.16

PubMed score by year
PubTator Score  67.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer