Protein Classes
Protein Summary
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
- ENST00000380420
- ENSP00000369785
- ENSG00000087842
- ENST00000380421
- ENSP00000369786
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
virus perturbation | 0.85 | ||
protein domain | 0.73 | ||
histone modification site profile | 0.68 | ||
gene perturbation | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 537.16 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 537.16 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (3)
Reactome (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Digestion | ||||
Reactome | Digestion and absorption | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Digestion | ||||
Digestion and absorption | ||||
Gene Ontology Terms (10)
Functions (3)
Components (4)
Processes (3)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Protein-Protein Interactions (70)
1 – 10 of 70
C2orf68
Novelty: 0.31818182
p_int: 0.999956631
p_ni: 0.000039701
p_wrong: 0.000003668
Score: 0.29
Data Source: BioPlex,STRINGDB
PUF60
Novelty: 0.0330882
p_int: 0.999496984
p_ni: 0.00050035
p_wrong: 0.000002666
Data Source: BioPlex
KLHL20
Novelty: 0.17747435
p_int: 0.992086641
p_ni: 0.007913319
p_wrong: 4e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
FGB
Novelty: 0.00757235
p_int: 0.981686064
p_ni: 0.018312455
p_wrong: 0.00000148
Data Source: BioPlex
WASF2
Novelty: 0.00106405
Score: 0.907
Data Source: STRINGDB
PSMA7
Family: Enzyme
Novelty: 0.00166058
Score: 0.905
Data Source: STRINGDB
NCKAP1
Novelty: 0.06198423
Score: 0.9
Data Source: STRINGDB
ABL2
Family: Kinase
Novelty: 0.01240347
Score: 0.9
Data Source: STRINGDB
NCK1
Novelty: 0.00554007
Score: 0.9
Data Source: STRINGDB
RAC1
Family: Enzyme
Novelty: 0.00579565
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score 537.16
PubMed score by year
PubTator Score 67.54
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: