Tbio CYR61 Protein CYR61

Protein Summary

Description

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• O00622
• O14934
• O43775
• Q9BZL7

Gene Name

• CYR61

Ensembl ID

• ENST00000451137
• ENSP00000398736
• ENSG00000142871

Symbol

• CCN1
• GIG1
• IGFBP10
• GIG1
• CYR61
• IGFBP10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
biological process	0.99
transcription factor perturbation	0.99
protein domain	0.97
small molecule perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Protein Cyr61

DTO Classes

Protein / Signaling / Growth Factor / Protein Cyr61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.39   (req: < 5)

Gene RIFs: 268   (req: <= 3)

Antibodies: 546   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.39   (req: >= 5)

Gene RIFs: 268   (req: > 3)

Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0