Protein Summary
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. This gene encodes a member of the sialomucin protein family. The encoded protein ...more
- ENST00000322985
- ENSP00000319782
- ENSG00000128567
- ENST00000378555
- ENSP00000367817
- PCLP
- PCLP1
- PC
- PCLP
- Gp200
- PCLP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.97 | ||
transcription factor perturbation | 0.96 | ||
cellular component | 0.92 | ||
microRNA | 0.8 | ||
histone modification site profile | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.92 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 1094 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.92 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 1094 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
SLC9A3R2
Family: Transporter
Novelty: 0.01401705
p_int: 0.999991394
p_ni: 0.000008605
p_wrong: 1e-9
Score: 0.873
Data Source: BioPlex,STRINGDB
FCN1
Novelty: 0.01037775
p_int: 0.999947112
p_ni: 0.000052888
Score: 0.188
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.999939026
p_ni: 0.000060969
p_wrong: 6e-9
Score: 0.292
Data Source: BioPlex,STRINGDB
LGALS9
Novelty: 0.00381766
p_int: 0.999937068
p_ni: 0.000062217
p_wrong: 7.15e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
RHPN1
Novelty: 0.05722992
p_int: 0.99985101
p_ni: 0.000148971
p_wrong: 1.9e-8
Data Source: BioPlex
HSPA12A
Novelty: 0.11999085
p_int: 0.999577225
p_ni: 0.000422775
Score: 0.162
Data Source: BioPlex,STRINGDB
NCR3LG1
Novelty: 0.02681936
p_int: 0.998174982
p_ni: 0.001825018
Score: 0.154
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
WikiPathways (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
WikiPathways | Hepatitis C and Hepatocellular Carcinoma | ||||
WikiPathways | Ectoderm Differentiation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Hepatitis C and Hepatocellular Carcinoma | ||||
Ectoderm Differentiation | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Components (15)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell density measurement | 1 | 1 | 1 | 9.5 | |||||
alcohol dependence measurement | 1 | 1 | 1 | 1.9 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 0.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell density measurement | 1 | 9.5 | |||||
alcohol dependence measurement | 1 | 1.9 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 0.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | podocalyxin like | VGNC:8735 | 472604 | |||||
Macaque | podocalyxin like | 704777 | ||||||
Mouse | MGI:1351317 | 27205 | ||||||
Rat | RGD:621878 | 192181 | ||||||
Dog | podocalyxin like | VGNC:54792 | 482252 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | podocalyxin like | |||||
Macaque | podocalyxin like | |||||
Mouse | ||||||
Rat | ||||||
Dog | podocalyxin like | |||||
Publication Statistics
PubMed Score 363.92
PubMed score by year
PubTator Score 194.21
PubTator score by year
Related Publications
Text Mined References (87)
GeneRif Annotations (65)
Items per page:
0 of 0
PMID | Year | Title |
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