Tbio PODXL Podocalyxin

Protein Summary

Description

Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00592
• A6NHX8
• Q52LZ7
• Q53ER6

Gene Name

• PODXL

Ensembl ID

• ENST00000322985
• ENSP00000319782
• ENSG00000128567
• ENST00000378555
• ENSP00000367817

Symbol

• PCLP
• PCLP1
• PC
• PCLP
• Gp200
• PCLP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.96
cellular component	0.92
microRNA	0.8
histone modification site profile	0.75

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.02   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 1094   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.02   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 1094   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1	1	1		6.2
alcohol dependence measurement	EFO_0007835	1	1	1		4.3
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1	1	1		0

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1		6.2
alcohol dependence measurement	EFO_0007835	1		4.3
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1		0

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Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	podocalyxin like	VGNC:8735	472604
Macaque	podocalyxin like		704777
Mouse	podocalyxin-like	MGI:1351317	27205
Rat	podocalyxin-like	RGD:621878	192181
Dog	podocalyxin like	VGNC:54792	482252

Species	Name	OMA	EggNOG	Inparanoid
Chimp	podocalyxin like
Macaque	podocalyxin like
Mouse	podocalyxin-like
Rat	podocalyxin-like
Dog	podocalyxin like

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O00592-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)

WikiPathways (3)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Primary Focal Segmental Glomerulosclerosis FSGS	184 targets	WP2572_r105791
WikiPathways	Hepatitis C and Hepatocellular Carcinoma	266 targets	WP3646_r105615
WikiPathways	Ectoderm Differentiation	350 targets	WP2858_r105577

Name	Explore in Pharos	Explore in Source
Primary Focal Segmental Glomerulosclerosis FSGS	184 targets	WP2572_r105791
Hepatitis C and Hepatocellular Carcinoma	266 targets	WP3646_r105615
Ectoderm Differentiation	350 targets	WP2858_r105577

Gene Ontology Terms (24)

Components (15)

Processes (9)

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10

1 – 10 of 15

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from Direct Assay (IDA)	UniProtKB
filopodium	Inferred from Direct Assay (IDA)	UniProtKB
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA
lamellipodium	Inferred from Direct Assay (IDA)	UniProtKB
microtubule organizing center	Inferred from Direct Assay (IDA)	HPA
nucleolus	Inferred from Direct Assay (IDA)	HPA
plasma membrane	Inferred from Direct Assay (IDA)	UniProtKB
ruffle	Inferred from Direct Assay (IDA)	UniProtKB
extracellular space	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (94)

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1 – 10 of 94

• See Interactions on String-DB

LGALS8

Tchem

Novelty: 0.00623836

p_int: 0.999992129

p_ni: 0.000007871

Data Source: BioPlex

SLC9A3R2

Tbio

Family: Transporter

Novelty: 0.01401705

p_int: 0.999991394

p_ni: 0.000008605

p_wrong: 1e-9

Score: 0.873

Data Source: BioPlex,STRINGDB

MRAP2

Tbio

Novelty: 0.0420503

p_int: 0.999988454

p_ni: 0.000011546

Data Source: BioPlex

CCR6

Tchem

Family: GPCR

Novelty: 0.00257933

p_int: 0.999965094

p_ni: 0.000034906

Data Source: BioPlex

FCN1

Tbio

Novelty: 0.01037775

p_int: 0.999947112

p_ni: 0.000052888

Score: 0.188

Data Source: BioPlex,STRINGDB

LGALS3

Tchem

Novelty: 0.00032754

p_int: 0.999939026

p_ni: 0.000060969

p_wrong: 6e-9

Score: 0.292

Data Source: BioPlex,STRINGDB

LGALS9

Tchem

Novelty: 0.00381766

p_int: 0.999937068

p_ni: 0.000062217

p_wrong: 7.15e-7

Score: 0.232

Data Source: BioPlex,STRINGDB

RHPN1

Tbio

Novelty: 0.05722992

p_int: 0.99985101

p_ni: 0.000148971

p_wrong: 1.9e-8

Data Source: BioPlex

HSPA12A

Tbio

Novelty: 0.11999085

p_int: 0.999577225

p_ni: 0.000422775

Score: 0.162

Data Source: BioPlex,STRINGDB

NCR3LG1

Tbio

Novelty: 0.02681936

p_int: 0.998174982

p_ni: 0.001825018

Score: 0.154

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  355.02

PubMed score by year

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PubTator Score  194.21

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

Agents acting on the renin-angiotensin system use measurement
alcohol dependence measurement
red blood cell density measurement

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype
respiratory system phenotype