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Tclin
GABRP
Gamma-aminobutyric acid receptor subunit pi

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265294
  • ENSP00000265294
  • ENSG00000094755
  • ENST00000518525
  • ENSP00000430100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.86
PubMedID
0.86
protein domain
0.85
tissue sample
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.19   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.19   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Approved Drugs (10)
1 – 10 of 10
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
70.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor pi subunit
VGNC:8621
471736
Macaque
gamma-aminobutyric acid type A receptor pi subunit
701113
Mouse
MGI:2387597
216643
Rat
RGD:620532
81658
Dog
gamma-aminobutyric acid type A receptor pi subunit
VGNC:41065
489124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor pi subunit
Macaque
gamma-aminobutyric acid type A receptor pi subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor pi subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00591-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
GABAergic synapse
KEGG
Nicotine addiction
KEGG
Neuroactive ligand-receptor interaction
KEGG
Morphine addiction
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
GABAergic synapse
Nicotine addiction
Neuroactive ligand-receptor interaction
Morphine addiction
Protein-Protein Interactions (77)
1 – 10 of 77
GPHN
Tbio
Novelty:  0.0020752
Score:  0.745
Data Source:  STRINGDB
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
Score:  0.722
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.72
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.715
Data Source:  STRINGDB
CLIC6
Tbio
Family:  IC
Novelty:  0.04037074
Score:  0.713
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.709
Data Source:  STRINGDB
GABRG1
Tclin
Family:  IC
Novelty:  0.04214561
Score:  0.709
Data Source:  STRINGDB
GABRG3
Tclin
Family:  IC
Novelty:  0.0420649
Score:  0.708
Data Source:  STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.707
Data Source:  STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.704
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.19

PubMed score by year
PubTator Score  9.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer