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Tbio
ACKR2
Atypical chemokine receptor 2

Protein Summary
Description
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemok ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422265
  • ENSP00000416996
  • ENSG00000144648
  • ENST00000442925
  • ENSP00000396150

Symbol
  • CCBP2
  • CCR10
  • CMKBR9
  • D6
  • D6
  • hD6
  • CCR9
  • CCBP2
  • CCR10
  • CMKBR9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
molecular function
0.73
tissue sample
0.66
cell line
0.61
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.68   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.68   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (101)
1 – 10 of 101
CDK18
Tchem
Family:  Kinase
Novelty:  0.053383
p_int:  0.95198665
p_ni:  0.048013319
p_wrong:  3.1e-8
Score:  0.39
Data Source:  BioPlex,STRINGDB
CCL25
Tbio
Novelty:  0.00824289
Score:  0.954
Data Source:  STRINGDB
CCL27
Tbio
Novelty:  0.00163457
Score:  0.89
Data Source:  STRINGDB
MADCAM1
Tbio
Novelty:  0.00325843
Score:  0.826
Data Source:  STRINGDB
CCL8
Tbio
Novelty:  0.00441336
Score:  0.779
Data Source:  STRINGDB
CCL11
Tbio
Novelty:  0.00086805
Score:  0.776
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.769
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.765
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.729
Data Source:  STRINGDB
CCL28
Tbio
Novelty:  0.00513161
Score:  0.729
Data Source:  STRINGDB
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
4
5
98.9
monocyte percentage of leukocytes
2
3
4
97.9
myeloid white cell count
2
3
3
94.4
granulocyte percentage of myeloid white cells
1
2
2
93.9
eotaxin measurement
1
3
3
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
98.9
monocyte percentage of leukocytes
4
97.9
myeloid white cell count
3
94.4
granulocyte percentage of myeloid white cells
2
93.9
eotaxin measurement
3
93.9
Find similar targets by:
Publication Statistics
PubMed Score 265.68
PubMed score by year
PubTator Score 71.64
PubTator score by year
Patents
Patents by year