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Tbio
MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Protein Summary
Description
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356998
  • ENSP00000349490
  • ENSG00000100060
  • ENST00000416983
  • ENSP00000413855
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
PubMedID
0.75
virus perturbation
0.72
tissue sample
0.68
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
3
3
88.7
cup-to-disc ratio measurement
3
3
4
88.4
optic disc area measurement
3
3
5
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
3
88.7
cup-to-disc ratio measurement
4
88.4
optic disc area measurement
5
81.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
458811
Macaque
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
699530
Mouse
MGI:1095404
17305
Rat
RGD:735126
315119
Dog
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
VGNC:43194
610303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Macaque
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00587-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Pre-NOTCH Expression and Processing (R-HSA-1912422)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Pre-NOTCH Expression and Processing
Reactome
Pre-NOTCH Processing in Golgi
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Name
Explore in Pharos
Explore in Source
Pre-NOTCH Expression and Processing
Pre-NOTCH Processing in Golgi
Signal Transduction
Signaling by NOTCH
Protein-Protein Interactions (36)
1 – 10 of 36
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.98
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.974
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.958
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.94
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.814
Data Source:  STRINGDB
JAG1
Tbio
Novelty:  0.00107618
Score:  0.812
Data Source:  STRINGDB
RFNG
Tdark
Family:  Enzyme
Novelty:  0.1966578
Score:  0.81
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.727
Data Source:  STRINGDB
JAG2
Tbio
Novelty:  0.00176158
Score:  0.687
Data Source:  STRINGDB
POFUT1
Tbio
Family:  Enzyme
Novelty:  0.0176011
Score:  0.629
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.62

PubMed score by year
PubTator Score  5.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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