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Tbio
RNASET2
Ribonuclease T2

Protein Summary
Description
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421787
  • ENSP00000390833
  • ENSG00000026297
  • ENST00000476238
  • ENSP00000422846
  • ENST00000508775
  • ENSP00000426455

Symbol
  • RNASE6PL
  • RNASE6PL
  • bA514O12.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
virus perturbation
0.88
kinase perturbation
0.81
histone modification site profile
0.71
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.45   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.45   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (121)
1 – 10 of 121
PDIA5
Tbio
Family: Enzyme
Novelty: 0.05109703
p_int: 0.987894056
p_ni: 0.012105944
Score: 0.319
Data Source: BioPlex,STRINGDB
FBXO2
Tbio
Novelty: 0.03751923
p_int: 0.976842145
p_ni: 0.023157684
p_wrong: 1.71e-7
Score: 0.241
Data Source: BioPlex,STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00182748
Score: 0.953
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00045103
Score: 0.948
Data Source: STRINGDB
NPC2
Tbio
Novelty: 0.00487879
Score: 0.931
Data Source: STRINGDB
C6orf120
Tdark
Novelty: 0.6440678
Score: 0.928
Data Source: STRINGDB
ADA2
Tbio
Family: Enzyme
Novelty: 0.01375983
Score: 0.926
Data Source: STRINGDB
CTSA
Tchem
Family: Enzyme
Novelty: 0.00073662
Score: 0.924
Data Source: STRINGDB
CREG1
Tbio
Novelty: 0.00998191
Score: 0.921
Data Source: STRINGDB
FUCA1
Tchem
Family: Enzyme
Novelty: 0.00435966
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.45

PubMed score by year
PubTator Score  76.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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