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Tbio
NOP56
Nucleolar protein 56

Protein Summary
Description
Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329276
  • ENSP00000370589
  • ENSG00000101361

Symbol
  • NOL5A
  • NOL5A
  • SCA36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
hub protein
0.97
kinase perturbation
0.96
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.18   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.18   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (568)
NOLC1
Tbio
Novelty:  0.01922261
p_int:  0.99603831
p_ni:  0.00396169
Score:  0.997
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.987905385
p_ni:  0.012094615
Score:  0.999
Data Source:  BioPlex,STRINGDB
KPNA6
Tbio
Novelty:  0.03516499
p_int:  0.942424639
p_ni:  0.057575361
Score:  0.529
Data Source:  BioPlex,STRINGDB
KPNA1
Tbio
Novelty:  0.00863582
p_int:  0.928749298
p_ni:  0.071250702
Score:  0.524
Data Source:  BioPlex,STRINGDB
EIF3J
Tbio
Novelty:  0.04648652
p_int:  0.91964792
p_ni:  0.077901905
p_wrong:  0.002450175
Data Source:  BioPlex
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.904405661
p_ni:  0.095594339
Score:  0.477
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.894323298
p_ni:  0.105676702
Score:  0.571
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.887900082
p_ni:  0.112099918
Score:  0.15
Data Source:  BioPlex,STRINGDB
KPNA5
Tbio
Novelty:  0.0762372
p_int:  0.884707944
p_ni:  0.115292056
Score:  0.218
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.873683194
p_ni:  0.126316805
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP56 ribonucleoprotein
VGNC:6216
458047
Macaque
NOP56 ribonucleoprotein
718202
Mouse
MGI:1914384
67134
Rat
RGD:1308892
362214
Dog
NOP56 ribonucleoprotein
VGNC:43891
612871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP56 ribonucleoprotein
Macaque
NOP56 ribonucleoprotein
Mouse
Rat
Dog
NOP56 ribonucleoprotein
Publication Statistics
PubMed Score 78.18
PubMed score by year
PubTator Score 28.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title