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Tbio
MPHOSPH10
U3 small nucleolar ribonucleoprotein protein MPP10

Protein Summary
Description
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244230
  • ENSP00000244230
  • ENSG00000124383

Symbol
  • MPP10
  • CT90
  • MPP10
  • MPP10P
  • PPP1R106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.92
drug perturbation
0.87
ligand (protein) perturbation
0.83
interacting protein
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.99984119
p_ni:  0.00015881
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.972040975
p_ni:  0.027959025
Score:  0.938
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.956584018
p_ni:  0.043415982
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.943768291
p_ni:  0.056231709
Score:  0.315
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.92389118
p_ni:  0.07610882
Score:  0.308
Data Source:  BioPlex,STRINGDB
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.874261411
p_ni:  0.125738589
Data Source:  BioPlex
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.86496944
p_ni:  0.13503056
Score:  0.222
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.80058092
p_ni:  0.19941908
Score:  0.909
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.768129411
p_ni:  0.231869879
p_wrong:  7.1e-7
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.763015438
p_ni:  0.236984562
Score:  0.352
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
21.4
eosinophil percentage of leukocytes
1
1
1
13.8
intelligence
1
1
0
5.6
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
21.4
eosinophil percentage of leukocytes
1
13.8
intelligence
0
5.6
0.9
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 10
VGNC:6400
459311
Macaque
M-phase phosphoprotein 10
704207
Mouse
MGI:1915223
67973
Rat
RGD:1307633
293828
Dog
M-phase phosphoprotein 10
VGNC:43335
612775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 10
Macaque
M-phase phosphoprotein 10
Mouse
Rat
Dog
M-phase phosphoprotein 10
Publication Statistics
PubMed Score 19.07
PubMed score by year
PubTator Score 11.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title