Tbio PITPNM1 Membrane-associated phosphatidylinositol transfer protein 1

Protein Summary

Description

Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O00562
• A6NME4
• Q6T7X3
• Q8TBN3
• Q9BZ73

Gene Name

• PITPNM1

Ensembl ID

• ENST00000356404
• ENSP00000348772
• ENSG00000110697
• ENST00000436757
• ENSP00000398787
• ENST00000534749
• ENSP00000437286

Symbol

• DRES9
• NIR2
• PITPNM
• Rd9
• NIR2
• RDGB
• DRES9
• RDGB1
• RDGBA
• PITPNM
• RDGBA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.98
disease perturbation	0.95
cellular component	0.81
transcription factor perturbation	0.8
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transporter / Membrane-associated Phosphatidylinositol Transfer Protein 1

Protein / Transfer/carrier Protein / Membrane-associated Phosphatidylinositol Transfer Protein 1

DTO Classes

Protein / Transporter / Membrane-associated Phosphatidylinositol Transfer Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.07   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.07   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0