Protein Summary
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role ...more
- ENST00000260130
- ENSP00000260130
- ENSG00000137575
- ENST00000413219
- ENSP00000411771
- ENST00000424270
- ENSP00000395351
- ENST00000447182
- ENSP00000409288
- MDA9
- SYCL
- ST1
- MDA9
- SYCL
- MDA-9
- TACIP18
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.97 | ||
virus perturbation | 0.94 | ||
cellular component | 0.92 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 443.2 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 463 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 443.2 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 463 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (211)
TARSL2
Family: Enzyme
Novelty: 0.02406282
p_int: 0.999942988
p_ni: 0.000057012
Score: 0.524
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.999764334
p_ni: 0.000235666
Score: 0.828
Data Source: BioPlex,STRINGDB
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999487762
p_ni: 0.000512238
Score: 0.821
Data Source: BioPlex,STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03283387
p_int: 0.997768809
p_ni: 0.002231191
Score: 0.815
Data Source: BioPlex,STRINGDB
PCDHGA7
Novelty: 1.67766171
p_int: 0.995036579
p_ni: 0.004955934
p_wrong: 0.000007487
Data Source: BioPlex
DARS
Family: Enzyme
Novelty: 0.01101888
p_int: 0.983480748
p_ni: 0.016519252
Score: 0.817
Data Source: BioPlex,STRINGDB
PSME2
Novelty: 0.02624268
p_int: 0.978393776
p_ni: 0.02068423
p_wrong: 0.000921994
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (9)
PathwayCommons (7)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | Ephrin signaling | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
Ephrin signaling | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (8)
Components (21)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 7 | 8 | 16 | 98.2 | |||||
total cholesterol measurement | 6 | 7 | 14 | 96 | |||||
triglyceride measurement | 4 | 4 | 5 | 93.9 | |||||
apolipoprotein B measurement | 2 | 3 | 3 | 92.2 | |||||
serum gamma-glutamyl transferase measurement | 2 | 3 | 3 | 88.1 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 16 | 98.2 | |||||
total cholesterol measurement | 14 | 96 | |||||
triglyceride measurement | 5 | 93.9 | |||||
apolipoprotein B measurement | 3 | 92.2 | |||||
serum gamma-glutamyl transferase measurement | 3 | 88.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syndecan binding protein | VGNC:800 | 464192 | |||||
Macaque | syndecan binding protein | 698381 | ||||||
Mouse | MGI:1337026 | 53378 | ||||||
Rat | RGD:621497 | 83841 | ||||||
Dog | syndecan binding protein | 482977 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syndecan binding protein | |||||
Macaque | syndecan binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | syndecan binding protein | |||||
Publication Statistics
PubMed Score 443.20
PubMed score by year
PubTator Score 275.44
PubTator score by year
Related Publications
Text Mined References (97)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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