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Tbio
SDCBP
Syntenin-1

Protein Summary
Description
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260130
  • ENSP00000260130
  • ENSG00000137575
  • ENST00000413219
  • ENSP00000411771
  • ENST00000424270
  • ENSP00000395351
  • ENST00000447182
  • ENSP00000409288

Symbol
  • MDA9
  • SYCL
  • ST1
  • MDA9
  • SYCL
  • MDA-9
  • TACIP18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
virus perturbation
0.94
cellular component
0.92
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 434.13   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 434.13   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
Ephrin signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
Ephrin signaling
Immune System
Gene Ontology Terms (49)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (211)
1 – 10 of 211
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
p_int: 0.999942988
p_ni: 0.000057012
Score: 0.524
Data Source: BioPlex,STRINGDB
AIMP1
Tbio
Family: Enzyme
Novelty: 0.00743447
p_int: 0.999764334
p_ni: 0.000235666
Score: 0.828
Data Source: BioPlex,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999487762
p_ni: 0.000512238
Score: 0.821
Data Source: BioPlex,STRINGDB
AIMP2
Tbio
Family: Enzyme
Novelty: 0.03283387
p_int: 0.997768809
p_ni: 0.002231191
Score: 0.815
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.99687154
p_ni: 0.00312846
Data Source: BioPlex
PCDHGA7
Tdark
Novelty: 1.67766171
p_int: 0.995036579
p_ni: 0.004955934
p_wrong: 0.000007487
Data Source: BioPlex
WRAP73
Tbio
Novelty: 0.25394934
p_int: 0.993808405
p_ni: 0.006191595
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.991972423
p_ni: 0.008027577
Data Source: BioPlex
DARS
Tbio
Family: Enzyme
Novelty: 0.01101888
p_int: 0.983480748
p_ni: 0.016519252
Score: 0.817
Data Source: BioPlex,STRINGDB
PSME2
Tbio
Novelty: 0.02624268
p_int: 0.978393776
p_ni: 0.02068423
p_wrong: 0.000921994
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  434.13

PubMed score by year
PubTator Score  275.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer