You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EBAG9
Receptor-binding cancer antigen expressed on SiSo cells

Protein Summary
Description
May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337573
  • ENSP00000337675
  • ENSG00000147654
  • ENST00000395785
  • ENSP00000379131
  • ENST00000531677
  • ENSP00000432082
  • ENST00000614147
  • ENSP00000477734
  • ENST00000620557
  • ENSP00000477645

Symbol
  • RCAS1
  • EB9
  • PDAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.79
cellular component
0.76
histone modification site profile
0.73
transcription factor binding site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.22   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.22   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor binding site associated, antigen, 9
464339
Macaque
estrogen receptor binding site associated, antigen, 9
699305
Mouse
MGI:1859920
55960
Rat
RGD:1307293
299864
Dog
estrogen receptor binding site associated, antigen, 9
VGNC:40174
403500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor binding site associated, antigen, 9
Macaque
estrogen receptor binding site associated, antigen, 9
Mouse
Rat
Dog
estrogen receptor binding site associated, antigen, 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00559-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Protein-Protein Interactions (30)
1 – 10 of 30
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.932
Data Source: STRINGDB
COX7A2L
Tbio
Family: Enzyme
Novelty: 0.06920916
Score: 0.907
Data Source: STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00457474
Score: 0.802
Data Source: STRINGDB
SNAPIN
Tbio
Novelty: 0.02019383
Score: 0.75
Data Source: STRINGDB
NUDCD1
Tbio
Novelty: 0.07471096
Score: 0.747
Data Source: STRINGDB
BLOC1S5
Tbio
Novelty: 0.17565466
Score: 0.679
Data Source: STRINGDB
ASNA1
Tbio
Family: Enzyme
Novelty: 0.01260233
Score: 0.677
Data Source: STRINGDB
STX12
Tbio
Novelty: 0.03836262
Score: 0.672
Data Source: STRINGDB
SNAP23
Tbio
Novelty: 0.0065371
Score: 0.665
Data Source: STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
Score: 0.66
Data Source: STRINGDB
Publication Statistics
PubMed Score  178.22

PubMed score by year
PubTator Score  65.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer