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Tbio
DLL1
Delta-like protein 1

Protein Summary
Description
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366756
  • ENSP00000355718
  • ENSG00000198719
  • ENST00000616526
  • ENSP00000480905
  • ENSG00000275555

Symbol
  • DL1
  • Delta
  • DELTA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.91
PubMedID
0.84
transcription factor
0.75
biological term
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753.96   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753.96   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
72.6
platelet crit
1
1
1
72.2
lymphocyte count
2
2
2
72.1
daytime rest measurement
1
1
1
51.4
hematocrit
2
2
2
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
72.6
platelet crit
1
72.2
lymphocyte count
2
72.1
daytime rest measurement
1
51.4
hematocrit
2
48.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 1
VGNC:52008
465121
Mouse
MGI:104659
13388
Rat
RGD:70949
84010
Dog
delta like canonical Notch ligand 1
VGNC:39986
100688936
Cow
delta like canonical Notch ligand 1
VGNC:28094
788775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 1
Mouse
Rat
Dog
delta like canonical Notch ligand 1
Cow
delta like canonical Notch ligand 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00548-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (50)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Gene Ontology Terms (69)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (131)
1 – 10 of 131
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.99
Data Source:  Reactome,STRINGDB
MIB1
Tbio
Family:  Enzyme
Novelty:  0.03288048
Score:  0.985
Data Source:  STRINGDB
NEURL1B
Tdark
Family:  Enzyme
Novelty:  0.16762429
Score:  0.972
Data Source:  STRINGDB
NEURL1
Tbio
Family:  Enzyme
Novelty:  0.05370537
Score:  0.971
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.966
Data Source:  Reactome,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.965
Data Source:  Reactome,STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.965
Data Source:  Reactome,STRINGDB
DTX1
Tbio
Family:  Enzyme
Novelty:  0.00972217
Score:  0.96
Data Source:  STRINGDB
ADAM17
Tchem
Family:  Enzyme
Novelty:  0.00121971
Score:  0.958
Data Source:  STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  753.96

PubMed score by year
PubTator Score  255.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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