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Tbio
CHL1
Neural cell adhesion molecule L1-like protein

Protein Summary
Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain canc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256509
  • ENSP00000256509
  • ENSG00000134121
  • ENST00000397491
  • ENSP00000380628

Symbol
  • CALL
  • CALL
  • L1CAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.86
PubMedID
0.77
microRNA
0.74
disease
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1901.16   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1901.16   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (27)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
Developmental Biology
L1CAM interactions
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (127)
1 – 10 of 127
ANK1
Tbio
Novelty: 0.00244978
p_int: 0.999998813
p_ni: 0.000001187
Score: 0.942
Data Source: BioPlex,Reactome,STRINGDB
ANK3
Tbio
Novelty: 0.0053727
p_int: 0.99999857
p_ni: 0.00000143
Score: 0.612
Data Source: BioPlex,STRINGDB
ANK2
Tbio
Novelty: 0.00681594
p_int: 0.999971248
p_ni: 0.000028752
Score: 0.64
Data Source: BioPlex,STRINGDB
LGALS1
Tchem
Novelty: 0.00134398
p_int: 0.934530156
p_ni: 0.065469844
Score: 0.206
Data Source: BioPlex,STRINGDB
CNTN6
Tbio
Novelty: 0.00780503
Score: 0.947
Data Source: Reactome,STRINGDB
NRP1
Tchem
Novelty: 0.00183532
Score: 0.931
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00074903
Score: 0.925
Data Source: Reactome,STRINGDB
ITGA1
Tbio
Novelty: 0.00994526
Score: 0.911
Data Source: Reactome,STRINGDB
ITGA2
Tbio
Novelty: 0.0018496
Score: 0.906
Data Source: Reactome,STRINGDB
ITGA10
Tbio
Novelty: 0.06947263
Score: 0.902
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1901.16

PubMed score by year
PubTator Score  93.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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