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Tbio
KRIT1
Krev interaction trapped protein 1

Protein Summary
Description
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340022
  • ENSP00000344668
  • ENSG00000001631
  • ENST00000394503
  • ENSP00000378011
  • ENST00000394505
  • ENSP00000378013
  • ENST00000394507
  • ENSP00000378015
  • ENST00000412043
  • ENSP00000410909

Symbol
  • CCM1
  • CAM
  • CCM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein domain
0.85
disease perturbation
0.83
microRNA
0.8
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.75   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.75   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (64)
1 – 10 of 64
CCM2
Tbio
Novelty: 0.01158059
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
ITGB1BP1
Tbio
Novelty: 0.0643874
p_int: 0.999998455
p_ni: 4e-9
p_wrong: 0.000001542
Score: 0.999
Data Source: BioPlex,STRINGDB
HEG1
Tbio
Novelty: 0.00741521
p_int: 0.999954476
p_ni: 0.000045524
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
SLC34A2
Tbio
Family: Transporter
Novelty: 0.00744043
p_int: 0.999773928
p_ni: 0.000226064
p_wrong: 8e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
UBFD1
Tdark
Novelty: 13
p_int: 0.997931808
p_ni: 0.000004304
p_wrong: 0.002063888
Score: 0.359
Data Source: BioPlex,STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00195699
Score: 0.994
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00466391
Score: 0.982
Data Source: STRINGDB
PDCD10
Tbio
Novelty: 0.01042747
Score: 0.95
Data Source: STRINGDB
SNX17
Tbio
Novelty: 0.05959005
Score: 0.944
Data Source: STRINGDB
CCM2L
Tdark
Novelty: 0.81553398
Score: 0.899
Data Source: STRINGDB
Publication Statistics
PubMed Score  171.75

PubMed score by year
PubTator Score  188.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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