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Tchem
FAAH
Fatty-acid amide hydrolase 1

Protein Summary
Description
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243167
  • ENSP00000243167
  • ENSG00000117480

Symbol
  • FAAH1
  • PSAB
  • FAAH-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
biological term
0.8
cell type or tissue
0.8
histone modification site profile
0.73
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 814.01   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 814.01   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1167
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1