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Tchem
STK25
Serine/threonine-protein kinase 25

Protein Summary
Description
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316586
  • ENSP00000325748
  • ENSG00000115694
  • ENST00000401869
  • ENSP00000385687
  • ENST00000403346
  • ENSP00000384162
  • ENST00000405585
  • ENSP00000385541
  • ENST00000405883
  • ENSP00000384444
  • ENST00000535007
  • ENSP00000446008
  • ENST00000543554
  • ENSP00000444886

Symbol
  • SOK1
  • YSK1
  • SOK1
  • YSK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.87
transcription factor binding site profile
0.87
biological process
0.79
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
neratinib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
19.1
Anilide use measurement
1
1
1
1.5
basophil percentage of leukocytes
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
19.1
Anilide use measurement
1
1.5
basophil percentage of leukocytes
1
0.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
PDCD10
Tbio
Novelty: 0.00683934
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
STK24
Tchem
Family: Kinase
Novelty: 0.00457236
p_int: 0.999999999
p_ni: 1e-9
Score: 0.864
Data Source: BioPlex,STRINGDB
STK26
Tchem
Family: Kinase
Novelty: 0.03633178
p_int: 0.999999998
p_ni: 2e-9
Score: 0.865
Data Source: BioPlex,STRINGDB
TAOK1
Tchem
Family: Kinase
Novelty: 0.01714291
p_int: 0.999999259
p_ni: 7.22e-7
p_wrong: 1.9e-8
Score: 0.516
Data Source: BioPlex,STRINGDB
CAB39
Tbio
Novelty: 0.01592402
p_int: 0.999993891
p_ni: 0.000006109
Score: 0.904
Data Source: BioPlex,STRINGDB
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
p_int: 0.999992609
p_ni: 0.00000739
p_wrong: 1e-9
Score: 0.258
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.999989873
p_ni: 0.000010126
Score: 0.47
Data Source: BioPlex,STRINGDB
GOLGA2
Tbio
Novelty: 0.00544771
p_int: 0.999988126
p_ni: 0.000011874
Score: 0.867
Data Source: BioPlex,STRINGDB
KIF20A
Tchem
Novelty: 0.01640924
p_int: 0.999948742
p_ni: 0.00005123
p_wrong: 2.9e-8
Score: 0.231
Data Source: BioPlex,STRINGDB
C4orf19
Tdark
Novelty: 2.1863624
p_int: 0.999931632
p_ni: 0.000068368
Score: 0.826
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.24

PubMed score by year
PubTator Score  19.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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