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Tbio
KPNA3
Importin subunit alpha-4

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably throug ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261667
  • ENSP00000261667
  • ENSG00000102753

Symbol
  • QIP2
  • SRP1
  • SRP4
  • IPOA4
  • hSRP1
  • SRP1gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
virus perturbation
0.98
transcription factor perturbation
0.88
transcription factor binding site profile
0.8
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.41   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.41   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
38.6
reticulocyte count
1
1
1
35.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
38.6
reticulocyte count
1
35.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 3
VGNC:7293
452722
Macaque
karyopherin subunit alpha 3
706925
Mouse
MGI:1100863
16648
Rat
RGD:1311339
361055
Dog
karyopherin subunit alpha 3
VGNC:42501
476909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 3
Macaque
karyopherin subunit alpha 3
Mouse
Rat
Dog
karyopherin subunit alpha 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00505-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Host Interactions with Influenza Factors
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Host Interactions with Influenza Factors
ISG15 antiviral mechanism
Protein-Protein Interactions (100)
1 – 10 of 100
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.995177389
p_ni: 0.004822611
Score: 0.16
Data Source: BioPlex,STRINGDB
KIF22
Tbio
Novelty: 0.0109594
p_int: 0.990691816
p_ni: 0.009308184
Score: 0.229
Data Source: BioPlex,STRINGDB
IER2
Tbio
Novelty: 0.03864806
p_int: 0.905735837
p_ni: 0.094264162
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
RCC1
Tbio
Novelty: 0.00260884
p_int: 0.839506113
p_ni: 0.160493887
Score: 0.936
Data Source: BioPlex,STRINGDB
B2M
Tbio
Novelty: 0.00011248
p_int: 0.814451147
p_ni: 0.185548853
Score: 0.19
Data Source: BioPlex,STRINGDB
NOP56
Tbio
Novelty: 0.01256937
p_int: 0.761591568
p_ni: 0.238408432
Score: 0.264
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.983
Data Source: STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.952
Data Source: STRINGDB
IPO9
Tbio
Novelty: 0.03978028
Score: 0.94
Data Source: STRINGDB
KPNA2
Tbio
Novelty: 0.00506958
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.41

PubMed score by year
PubTator Score  25.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer