Tbio CLDN5 Claudin-5

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-5

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-5

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

Uniprot Accession IDs

• O00501
• B3KS11
• Q53XW2
• Q8WUW3

Gene Name

• CLDN5

Ensembl ID

• ENST00000618236
• ENSP00000480623
• ENSG00000184113

Symbol

• AWAL
• TMVCF
• AWAL
• BEC1
• TMVCF
• TMDVCF
• CPETRL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
gene perturbation	0.74
cellular component	0.7
tissue	0.65
cell type or tissue	0.6

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.26   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 413   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.26   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	claudin 5	MGI:1276112	12741
Rat	claudin 5	RGD:68431	65131
Cow	claudin 5	VGNC:27417	617453
Chicken	claudin 5	CGNC:49011	374028
Xenopus	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)	XB-GENE-976044	448343

Species	Name	OMA	EggNOG	Inparanoid
Mouse	claudin 5
Rat	claudin 5
Cow	claudin 5
Chicken	claudin 5
Xenopus	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O00501-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)

Reactome (9)

KEGG (4)

WikiPathways (5)

Cell junction organization (R-HSA-446728)

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Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (17)

Functions (2)

Components (6)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (110)

Explore Interacting Targets

1 – 10 of 110

• See Interactions on String-DB

CLDN12

Tbio

Novelty: 0.04404633

Score: 0.976

Data Source: STRINGDB

OCLN

Tbio

Novelty: 0.00047671

Score: 0.973

Data Source: STRINGDB

TJP1

Tbio

Novelty: 0.00040365

Score: 0.943

Data Source: STRINGDB

CLDN3

Tbio

Novelty: 0.00286252

Score: 0.939

Data Source: STRINGDB

CLDN23

Tbio

Novelty: 0.12349944

Score: 0.934

Data Source: STRINGDB

CLDN16

Tbio

Novelty: 0.0092505

Score: 0.924

Data Source: STRINGDB

CLDN11

Tbio

Novelty: 0.00275436

Score: 0.919

Data Source: STRINGDB

CLDN18

Tbio

Novelty: 0.01299528

Score: 0.918

Data Source: STRINGDB

CDH5

Tbio

Novelty: 0.00072649

Score: 0.915

Data Source: STRINGDB

CLDN2

Tbio

Novelty: 0.00299455

Score: 0.912

Data Source: STRINGDB

Publication Statistics

PubMed Score  561.26

PubMed score by year

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PubTator Score  235.79

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Cell junction
Cell membrane
Complete proteome
Membrane
Reference proteome
Tight junction
Transmembrane
Transmembrane helix

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
mortality/aging
nervous system phenotype