Pharos : Target Details

Tbio

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

Uniprot Accession IDs

Gene Name

CLDN5

Ensembl ID

ENST00000618236
ENSP00000480623
ENSG00000184113

Symbol

AWAL
TMVCF
AWAL
BEC1
TMVCF
TMDVCF
CPETRL1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93

gene perturbation	0.74

cellular component	0.7

tissue	0.65

cell type or tissue	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.49 (req: < 5)

View Publications

Gene RIFs: 73 (req: <= 3)

View Gene RIFs

Antibodies: 413 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.49 (req: >= 5)

Gene RIFs: 73 (req: > 3)

Antibodies: 413 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (110)

1 – 10 of 110

See Interactions on String-DB

CLDN12

Tbio

Novelty: 0.04404633

Score: 0.976

Data Source: STRINGDB

OCLN

Tbio

Novelty: 0.00047671

Score: 0.973

Data Source: STRINGDB

TJP1

Tbio

Novelty: 0.00040365

Score: 0.943

Data Source: STRINGDB

CLDN3

Tbio

Novelty: 0.00286252

Score: 0.939

Data Source: STRINGDB

CLDN23

Tbio

Novelty: 0.12349944

Score: 0.934

Data Source: STRINGDB

CLDN16

Tbio

Novelty: 0.0092505

Score: 0.924

Data Source: STRINGDB

CLDN11

Tbio

Novelty: 0.00275436

Score: 0.919

Data Source: STRINGDB

CLDN18

Tbio

Novelty: 0.01299528

Score: 0.918

Data Source: STRINGDB

CDH5

Tbio

Novelty: 0.00072649

Score: 0.915

Data Source: STRINGDB

CLDN2

Tbio

Novelty: 0.00299455

Score: 0.912

Data Source: STRINGDB

Pathways (18)

Reactome (9)

KEGG (4)

WikiPathways (5)

Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728

Reactome	Cell-Cell communication	121 targets	R-HSA-1500931

Reactome	Cell-cell junction organization	63 targets	R-HSA-421270

Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728

Cell-Cell communication	121 targets	R-HSA-1500931

Cell-cell junction organization	63 targets	R-HSA-421270

Gene expression (Transcription)	1452 targets	R-HSA-74160

Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (17)

Functions (2)

Components (6)

Processes (9)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood protein measurement	EFO_0007937	1	1	1		5.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood protein measurement	EFO_0007937	1		5.9

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
Cell junction

Cell membrane

Complete proteome

Membrane

Reference proteome

Tight junction

Transmembrane

Transmembrane helix

GWAS Trait

No Header	No Header
blood protein measurement

MGI Phenotype

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID
Mouse	claudin 5	MGI:1276112	12741

Rat	claudin 5	RGD:68431	65131

Cow	claudin 5	VGNC:27417	617453

Chicken	claudin 5	CGNC:49011	374028

Xenopus	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)	XB-GENE-976044	448343

Species	Name	OMA	EggNOG	Inparanoid
Mouse	claudin 5

Rat	claudin 5

Cow	claudin 5

Chicken	claudin 5

Xenopus	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

Publication Statistics

PubMed Score 587.49

PubMed score by year

PubTator Score 235.79

PubTator score by year

No Header	No Header
cardiovascular system phenotype

mortality/aging

nervous system phenotype