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Tbio
CLDN5
Claudin-5

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618236
  • ENSP00000480623
  • ENSG00000184113

Symbol
  • AWAL
  • TMVCF
  • AWAL
  • BEC1
  • TMVCF
  • TMDVCF
  • CPETRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.74
cellular component
0.7
tissue
0.65
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.49   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.49   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.976
Data Source:  STRINGDB
OCLN
Tbio
Novelty:  0.00047671
Score:  0.973
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.943
Data Source:  STRINGDB
CLDN3
Tbio
Novelty:  0.00286252
Score:  0.939
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.934
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.924
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.919
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.918
Data Source:  STRINGDB
CDH5
Tbio
Novelty:  0.00072649
Score:  0.915
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1276112
12741
Rat
RGD:68431
65131
Cow
claudin 5
VGNC:27417
617453
Chicken
claudin 5
CGNC:49011
374028
Xenopus
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
XB-GENE-976044
448343
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
claudin 5
Chicken
claudin 5
Xenopus
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
Publication Statistics
PubMed Score 587.49
PubMed score by year
PubTator Score 235.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title