Protein Classes
Protein Summary
Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
- ENST00000618236
- ENSP00000480623
- ENSG00000184113
- AWAL
- TMVCF
- AWAL
- BEC1
- TMVCF
- TMDVCF
- CPETRL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.93 | ||
gene perturbation | 0.74 | ||
cellular component | 0.7 | ||
tissue | 0.65 | ||
cell type or tissue | 0.6 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.26 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 413 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.26 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 413 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (18)
Reactome (9)
KEGG (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (17)
Functions (2)
Components (6)
Processes (9)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (110)
1 – 10 of 110
CLDN12
Novelty: 0.04404633
Score: 0.976
Data Source: STRINGDB
OCLN
Novelty: 0.00047671
Score: 0.973
Data Source: STRINGDB
TJP1
Novelty: 0.00040365
Score: 0.943
Data Source: STRINGDB
CLDN3
Novelty: 0.00286252
Score: 0.939
Data Source: STRINGDB
CLDN23
Novelty: 0.12349944
Score: 0.934
Data Source: STRINGDB
CLDN16
Novelty: 0.0092505
Score: 0.924
Data Source: STRINGDB
CLDN11
Novelty: 0.00275436
Score: 0.919
Data Source: STRINGDB
CLDN18
Novelty: 0.01299528
Score: 0.918
Data Source: STRINGDB
CDH5
Novelty: 0.00072649
Score: 0.915
Data Source: STRINGDB
CLDN2
Novelty: 0.00299455
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score 561.26
PubMed score by year
PubTator Score 235.79
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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