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Tbio
BTN3A1
Butyrophilin subfamily 3 member A1

Protein Summary
Description
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289361
  • ENSP00000289361
  • ENSG00000026950
  • ENST00000414912
  • ENSP00000406667
  • ENST00000425234
  • ENSP00000396684
  • ENST00000476549
  • ENSP00000420010

Symbol
  • BTF5
  • BTF5
  • BT3.1
  • CD277
  • BTN3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.9
cell type or tissue
0.77
tissue sample
0.64
microRNA
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.52   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.52   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
89.4
unipolar depression
2
1
1
1.1
70.6
1
1
0
1.2
60
intelligence
2
2
2
6.7
55.6
1
1
0
1.1
18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
89.4
unipolar depression
1
1.1
70.6
0
1.2
60
intelligence
2
6.7
55.6
0
1.1
18
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00481-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (23)
1 – 10 of 23
BTN3A3
Tdark
Novelty: 0.1953685
p_int: 0.999999811
p_ni: 5.7e-8
p_wrong: 1.32e-7
Score: 0.775
Data Source: BioPlex,STRINGDB
BTN3A2
Tbio
Novelty: 0.06889505
p_int: 0.999999242
p_ni: 3.4e-7
p_wrong: 4.19e-7
Score: 0.928
Data Source: BioPlex,STRINGDB
TAOK3
Tchem
Family: Kinase
Novelty: 0.02065821
p_int: 0.999998338
p_ni: 4e-9
p_wrong: 0.000001657
Data Source: BioPlex
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999976449
p_ni: 0.000023542
p_wrong: 9e-9
Data Source: BioPlex
UACA
Tbio
Novelty: 0.05853699
p_int: 0.999952734
p_ni: 0.000047265
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.99839455
p_ni: 0.001604904
p_wrong: 5.46e-7
Data Source: BioPlex
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
p_int: 0.997026348
p_ni: 0.002963375
p_wrong: 0.000010277
Data Source: BioPlex
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
p_int: 0.972981646
p_ni: 0.027016158
p_wrong: 0.000002196
Data Source: BioPlex
ADD3
Tbio
Family: Enzyme
Novelty: 0.02164464
p_int: 0.914210092
p_ni: 0.085784542
p_wrong: 0.000005366
Data Source: BioPlex
VEZT
Tbio
Novelty: 0.06274137
p_int: 0.894184222
p_ni: 0.001839011
p_wrong: 0.103976767
Data Source: BioPlex
Publication Statistics
PubMed Score  47.52

PubMed score by year
PubTator Score  25.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer