Tchem BTN3A1 Butyrophilin subfamily 3 member A1

Protein Summary

Description

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• O00481
• A2A278
• A8K2C8
• B4DIQ1
• B4DRM2
• E9PGB4
• E9PHG8
• Q0P515
• Q147X5
• Q53F15
• Q99420
• Q9HCY1

Gene Name

• BTN3A1

Ensembl ID

• ENST00000289361
• ENSP00000289361
• ENSG00000026950
• ENST00000414912
• ENSP00000406667
• ENST00000425234
• ENSP00000396684
• ENST00000476549
• ENSP00000420010

Symbol

• BTF5
• BTF5
• BT3.1
• CD277
• BTN3.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.9
cell type or tissue	0.77
tissue sample	0.64
microRNA	0.61

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Butyrophilin Subfamily 3 Member A1

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Butyrophilin Subfamily 3 Member A1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.83   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.83   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2