Tdark HMGN4 High mobility group nucleosome-binding domain-containing protein 4

Protein Summary

Description

The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• O00479
• B2R4I6
• Q53XL9

Gene Name

• HMGN4

Ensembl ID

• ENST00000377575
• ENSP00000366798
• ENSG00000182952

Symbol

• HMG17L3
• NHC
• NHC
• HMG17L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.69
transcription factor binding site profile	0.61
PubMedID	0.58
co-expressed gene	0.57

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / High Mobility Group Nucleosome-binding Domain-containing Protein 4

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / High Mobility Group Nucleosome-binding Domain-containing Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0