Tbio ELL2 RNA polymerase II elongation factor ELL2

Protein Summary

Description

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.

Uniprot Accession IDs

• O00472
• B4DNK7

Gene Name

• ELL2

Ensembl ID

• ENST00000237853
• ENSP00000237853
• ENSG00000118985

Symbol

• MRCCAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
transcription factor perturbation	0.91
gene perturbation	0.88
PubMedID	0.88
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Rna Polymerase Ii Elongation Factor Ell2

Protein / Cell Junction Protein / Tight Junction / Rna Polymerase Ii Elongation Factor Ell2

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Rna Polymerase Ii Elongation Factor Ell2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.02   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.02   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0