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Tbio
AGRN
Agrin

Protein Summary
Description
Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379370
  • ENSP00000368678
  • ENSG00000188157

Symbol
  • AGRIN
  • CMS8
  • AGRIN
  • CMSPPD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.95
molecular function
0.88
virus perturbation
0.88
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.51   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.51   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone size
1
1
1
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone size
1
56.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
agrin
VGNC:48969
100609326
Macaque
agrin
700400
Mouse
MGI:87961
11603
Rat
RGD:2067
25592
Dog
agrin
VGNC:37716
479574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
agrin
Macaque
agrin
Mouse
Rat
Dog
agrin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00468-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (88)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Axon guidance
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Axon guidance
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (199)
1 – 10 of 199
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999985397
p_ni: 0.000014596
p_wrong: 8e-9
Score: 0.202
Data Source: BioPlex,STRINGDB
HADHA
Tbio
Novelty: 0.00385746
p_int: 0.999979003
p_ni: 0.000020985
p_wrong: 1.2e-8
Data Source: BioPlex
CRP
Tbio
Novelty: 0.00001517
p_int: 0.999966555
p_ni: 0.000033443
p_wrong: 2e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.999626037
p_ni: 0.00035002
p_wrong: 0.000023943
Data Source: BioPlex
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.996951098
p_ni: 0.002882733
p_wrong: 0.000166168
Data Source: BioPlex
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.991257591
p_ni: 0.008725881
p_wrong: 0.000016528
Data Source: BioPlex
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.852737425
p_ni: 0.000225314
p_wrong: 0.147037261
Data Source: BioPlex
OLFM3
Tbio
Novelty: 0.10234408
p_int: 0.847916659
p_ni: 0.000771509
p_wrong: 0.151311832
Score: 0.282
Data Source: BioPlex,STRINGDB
MUSK
Tchem
Family: Kinase
Novelty: 0.00151518
Score: 0.997
Data Source: Reactome,STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.996
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  672.51

PubMed score by year
PubTator Score  375.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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