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Tbio
TRAF5
TNF receptor-associated factor 5

Protein Classes
Protein Summary
Description
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261464
  • ENSP00000261464
  • ENSG00000082512
  • ENST00000336184
  • ENSP00000336825
  • ENST00000367004
  • ENSP00000355971

Symbol
  • RNF84
  • RNF84
  • MGC:39780
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.82
cell type or tissue
0.76
kinase perturbation
0.76
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
24.1
mathematical ability
1
1
1
13.5
household income
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
24.1
mathematical ability
1
13.5
household income
1
3.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TNF receptor associated factor 5
711879
Mouse
MGI:107548
22033
Rat
Dog
TNF receptor associated factor 5
VGNC:47769
480019
Horse
TNF receptor associated factor 5
VGNC:24461
100055119
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TNF receptor associated factor 5
Mouse
Rat
Dog
TNF receptor associated factor 5
Horse
TNF receptor associated factor 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00463-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Small cell lung cancer
KEGG
TNF signaling pathway
KEGG
Necroptosis
KEGG
NOD-like receptor signaling pathway
KEGG
IL-17 signaling pathway
Name
Explore in Pharos
Explore in Source
Small cell lung cancer
TNF signaling pathway
Necroptosis
NOD-like receptor signaling pathway
IL-17 signaling pathway
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (118)
1 – 10 of 118
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.99999998
p_ni: 1.2e-8
p_wrong: 9e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
HOMER1
Tbio
Novelty: 0.00264721
p_int: 0.999998649
p_ni: 0.00000135
p_wrong: 1e-9
Score: 0.715
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.999993531
p_ni: 0.000005088
p_wrong: 0.000001381
Data Source: BioPlex
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.999493191
p_ni: 0.0000573
p_wrong: 0.000449508
Score: 0.647
Data Source: BioPlex,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.982
Data Source: STRINGDB
TNFRSF13B
Tbio
Novelty: 0.00338954
Score: 0.963
Data Source: STRINGDB
TRADD
Tbio
Novelty: 0.00560091
Score: 0.957
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.952
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.95
Data Source: STRINGDB
RIPK1
Tchem
Family: Kinase
Novelty: 0.00230565
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.06

PubMed score by year
PubTator Score  36.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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