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Tchem
MANBA
Beta-mannosidase

Protein Summary
Description
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226578
  • ENSP00000226578
  • ENSG00000109323
  • ENST00000647097
  • ENSP00000495247

Symbol
  • MANB1
  • MANB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.89
PubMedID
0.8
transcription factor binding site profile
0.79
disease
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL62552
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
97.3
lymphocyte count
3
3
3
92.5
glomerular filtration rate
2
2
2
71.7
monocyte count
1
1
1
56.8
Sarcoidosis
1
1
0
1.2
52.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
97.3
lymphocyte count
3
92.5
glomerular filtration rate
2
71.7
monocyte count
1
56.8
Sarcoidosis
0
1.2
52.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase beta
VGNC:7047
461407
Macaque
mannosidase beta
712531
Mouse
MGI:88175
110173
Rat
RGD:1305785
310864
Dog
mannosidase beta
VGNC:42948
487883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase beta
Macaque
mannosidase beta
Mouse
Rat
Dog
mannosidase beta
Pathways (9)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Lysosomal oligosaccharide catabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Lysosomal oligosaccharide catabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (144)
1 – 10 of 144
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.995183382
p_ni: 0.004816618
Data Source: BioPlex
MFAP5
Tbio
Novelty: 0.01839035
p_int: 0.99210774
p_ni: 0.00789226
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.991790023
p_ni: 0.008209977
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.973196729
p_ni: 0.026803271
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.967389229
p_ni: 0.032610771
Score: 0.168
Data Source: BioPlex,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.965282076
p_ni: 0.034717924
Data Source: BioPlex
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.958736242
p_ni: 0.041263758
Data Source: BioPlex
IL25
Tbio
Novelty: 0.01620324
p_int: 0.958610471
p_ni: 0.041389529
Data Source: BioPlex
COL20A1
Tdark
Novelty: 0.39788946
p_int: 0.957732373
p_ni: 0.042267599
p_wrong: 2.8e-8
Data Source: BioPlex
RAMP1
Tclin
Novelty: 0.00831253
p_int: 0.953049669
p_ni: 0.046950316
p_wrong: 1.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  92.71

PubMed score by year
PubTator Score  149.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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